Cytotoxic Effects of Phosphonate-Functionalized Mesoporous Silica Nanoparticles
| العنوان: | Cytotoxic Effects of Phosphonate-Functionalized Mesoporous Silica Nanoparticles |
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| المؤلفون: | Nandita Menon, David Tai Leong |
| المصدر: | ACS Applied Materials & Interfaces. 8:2416-2422 |
| بيانات النشر: | American Chemical Society (ACS), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Programmed cell death, animal structures, Materials science, Cell Survival, Silicon dioxide, Static Electricity, Organophosphonates, Nanoparticle, Nanotechnology, 02 engineering and technology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Humans, Cytotoxic T cell, General Materials Science, Particle Size, Fibroblast, Cell Death, Mesoporous silica, Cell cycle, Silicon Dioxide, 021001 nanoscience & nanotechnology, Phosphonate, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Hydrodynamics, MCF-7 Cells, Biophysics, Nanoparticles, sense organs, 0210 nano-technology, Porosity |
| الوصف: | In this work, we synthesized pristine mesoporous silica nanoparticles (MSN) and functionalized these with phosphonate groups (MSN-Phos). We report, for the first time, cell death in MCF-7 cells (human breast adenocarcinoma cell line) when exposed to the empty MSN and MSN-Phos nanoparticles. In comparison, the same nanoparticles were found to elicit few deleterious effects on normal human foreskin fibroblast cells (BJ cells). MCF-7 cells were found to exhibit a concentration-dependent uptake, whereas no detectable nanoparticle uptake was observed in the BJ cells, irrespective of treatment dosage. A disruption of the cell cycle in the MCF-7 cells was determined to be the cause of cell death from the nanoparticle exposure, thereby suggesting the role of nondrug loaded MSN and MSN-Phos as effective anticancer drugs. |
| تدمد: | 1944-8252 1944-8244 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d63e70ee7b189330b93d883c021c32 https://doi.org/10.1021/acsami.5b11741 |
| رقم الأكسشن: | edsair.doi.dedup.....e3d63e70ee7b189330b93d883c021c32 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 19448252 19448244 |
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