Influence of a TNF-α Polymorphism on the Severity of Schistosomiasis Periportal Fibrosis in the Northeast of Brazil
العنوان: | Influence of a TNF-α Polymorphism on the Severity of Schistosomiasis Periportal Fibrosis in the Northeast of Brazil |
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المؤلفون: | Adriana Vieira Gomes, Jamile Luciana da Silva, Paula Carolina Valença Silva, Ana Lúcia Coutinho Domingues, Maria Tereza Cartaxo Muniz, Lidiane Régia Pereira Braga de Britto, Silvia Maria Lucena Montenegro, Elker Lene Santos de Lima |
المصدر: | Genetic testing and molecular biomarkers. 21(11) |
سنة النشر: | 2017 |
مصطلحات موضوعية: | 0301 basic medicine, Adult, Liver Cirrhosis, Male, Pathology, medicine.medical_specialty, Genotype, Schistosomiasis, Biology, Polymorphism, Single Nucleotide, Proinflammatory cytokine, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Mediator, Immune system, Risk Factors, medicine, Humans, Genetics (clinical), Aged, Tumor Necrosis Factor-alpha, General Medicine, Middle Aged, medicine.disease, Fibrosis, Schistosomiasis mansoni, 030104 developmental biology, Cross-Sectional Studies, Periportal fibrosis, 030220 oncology & carcinogenesis, Immunology, Tumor necrosis factor alpha, Female, Brazil |
الوصف: | The proinflammatory cytokine tumor necrosis factor-alpha (TNF-α) is an essential component in the host immune response to infection, and it has been reported to be an important mediator in severe periportal fibrosis (PPF). We hypothesized that the (-G308A) polymorphism of the TNF-α gene is associated with the severity of PPF and that these polymorphisms influence TNF-α expression.In this cross-sectional study, we genotyped these polymorphisms within the TNF-α gene in 256 Brazilian subjects infected with Schistosoma mansoni, with different patterns of PPF.The genotype (-308) AA was associated with a significant increase in the risk to advanced PPF (OR = 4.60; p = 0.009). In addition, median levels of TNF-α were higher in patients with moderate to advanced PPF, compared with mild fibrosis (20 and 17.3 pg/mL, respectively; p = 0.040). There was no association between average serum levels of TNF-α and (-G308A) TNF-α polymorphism.Our results suggest the (-308) AA genotype may be a risk factor for severity in advanced PPF, in this Brazilian population, and could potentially be used to predict the severity of advanced PPF in schistosomiasis. |
تدمد: | 1945-0257 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49f8a948a3ca3afaef0a42c503ca838 https://pubmed.ncbi.nlm.nih.gov/29087736 |
حقوق: | CLOSED |
رقم الأكسشن: | edsair.doi.dedup.....e49f8a948a3ca3afaef0a42c503ca838 |
قاعدة البيانات: | OpenAIRE |
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