Exploring the middle ear function in patients with a cluster of symptoms including tinnitus, hyperacusis, ear fullness and/or pain
| العنوان: | Exploring the middle ear function in patients with a cluster of symptoms including tinnitus, hyperacusis, ear fullness and/or pain |
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| المؤلفون: | Philippe Fournier, Dany Paleressompoulle, Marie-José Esteve Fraysse, Fabien Paolino, Arnaud Devèze, Frédéric Venail, Arnaud Noreña |
| المساهمون: | Laboratoire de Neurosciences Cognitives [Marseille] (LNC), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Méditerranéen de Recherche et de Traitement des Acouphènes (IMERTA), Hôpital Privé Clairval [Marseille], Department of Otology and Skull Base Surgery, Ramsay Health Care, Clairval Hospital, 317 Bd du Redon, 13009 Marseille, France, Clairval Hospital, Laboratory of Applied Biomechanisms, Faculty of Medicine, Aix-Marseille University, Service hospitalo-universitaire de médecine et santé au travail, Faculté des Sciences Médicales et Paramédicales, AP-HM La Timone, Aix Marseille Univ 27, boulevard Jean Moulin, Marseille Cedex 5 13385, France, Institut des Neurosciences de Montpellier (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Aix Marseille Université (AMU) |
| المصدر: | Hearing Research Hearing Research, 2022, 422, pp.108519. ⟨10.1016/j.heares.2022.108519⟩ |
| بيانات النشر: | HAL CCSD, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio], Sensory Systems |
| الوصف: | Middle ear muscle (MEM) abnormalities have been proposed to be involved in the development of ear-related symptoms such as tinnitus, hyperacusis, ear fullness, dizziness and/or otalgia. This cluster of symptoms have been called the Tonic Tensor Tympani Syndrome (TTTS) because of the supposed involvement of the tensor tympani muscle (TTM). However, the putative link between MEM dysfunction and the symptoms has not been proven yet and the detailed mechanisms (the causal chain) of TTTS are still elusive. It has been speculated that sudden loud sound (acoustic shock) may impair the functioning of the MEM, specifically the TTM, after an excessive contraction. This would result in inflammatory processes, activation of the trigeminal nerve and a change of the MEMs state into a hypersensitive one, that may be associated to the cluster of symptoms listed above. The goal of this study is to provide further insights into the mechanisms of TTTS. The middle ear function of 11 patients who reported TTTS symptoms has been investigated using either admittancemetry and/or measurement of air pressure in the sealed external auditory canal. While the former method measured the middle ear stiffness the latter provides an estimate of the tympanic membrane displacement. Most patients displayed results consistent with phasic contractions of the TTM (n = 9) and/or Eustachian Tube (ET) dysfunction (n = 6). The MEM contraction or ET dysfunction could be evoked by acoustic stimulation (n = 3), somatic maneuvers (n = 3), or pressure changes in the ear canal (n = 3). Spontaneous TTM contraction (n = 1) or ET opening (n = 1) could also be observed. Finally, voluntary contraction of MEM was also reported (n = 5). On the other hand, tonic contraction of the TTM could not be observed in any patient. The implications of these results for the mechanisms of TTTS are discussed. |
| اللغة: | English |
| تدمد: | 0378-5955 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4fcea1ce72b7f9e965b4de4b8b0c5f7 https://hal.science/hal-03848725 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....e4fcea1ce72b7f9e965b4de4b8b0c5f7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03785955 |
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