Management of Central Nervous System Infections, Vientiane, Laos, 2003–2011
| العنوان: | Management of Central Nervous System Infections, Vientiane, Laos, 2003–2011 |
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| المؤلفون: | Phonelavanh Phoumin, Amphonesavanh Sengduangphachanh, Rattanaphone Phetsouvanh, Mary-Anne Burns, Scott B. Craig, Valy Keoluangkot, Audrey Dubot-Pérès, Olay Lattana, Khonesavanh Luangxay, Prasith Phimmasone, Koukeo Phommasone, Sue J. Lee, Manivanh Vongsouvath, Kongkham Sisout, David A. B. Dance, Amphaivanh Seubsanith, Catrin E. Moore, Mayfong Mayxay, Khamsai Detleuxay, Vilada Chansamouth, Viengmon Davong, Sabine Dittrich, Xavier de Lamballerie, S. M. Tulsiani, Stuart D. Blacksell, Inpanh Phouangsouvanh, Sayaphet Rattanavong, Phonepasith Panyanivong, Paul N. Newton, Anisone Chanthongthip, Bountoy Sibounheuang, Manivone Simmalavong, Joy Sirisouk, Davanh Sengdatka |
| المساهمون: | Unité des Virus Emergents (UVE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Mahidol University [Bangkok]-Mahosot Hospital, University of Health Sciences, Mahidol Oxford Tropical Medicine Research Unit (MORU), Wellcome Trust-Mahidol University [Bangkok]-University of Oxford [Oxford], Nuffield Department of Clinical Medicine [Oxford], University of Oxford [Oxford], Mahosot Hospital, Queensland Health Forensic and Scientific Services, London School of Hygiene and Tropical Medicine (LSHTM), This work was supported by the Wellcome Trust of Great Britain, the Institute of Research for Development, AixMarseille University, and the European Union’s Horizon 2020 research and innovation program European Virus Archive global (grant agreement no. 653316)., European Project: 653316,H2020,H2020-INFRAIA-2014-2015,EVAg(2015), Graduate School, AII - Infectious diseases, APH - Global Health, APH - Methodology, University of Oxford-Mahidol University [Bangkok]-Wellcome Trust, University of Oxford, BUISINE, Soline, European Virus Archive goes global - EVAg - - H20202015-04-01 - 2019-03-31 - 653316 - VALID |
| المصدر: | Emerging Infectious Diseases Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2019, 25 (5), pp.898-910. ⟨10.3201/eid2505.180914⟩ Emerging Infectious Diseases, Vol 25, Iss 5, Pp 898-910 (2019) Emerging infectious diseases, 25(5), 898-910. Centers for Disease Control and Prevention (CDC) Emerging Infectious Diseases, 2019, 25 (5), pp.898-910. ⟨10.3201/eid2505.180914⟩ |
| بيانات النشر: | HAL CCSD, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Infectious Encephalitis, Male, Orientia tsutsugamushi, Epidemiology, encephalitis, Antibiotics, Cryptococcus, lcsh:Medicine, antibiotics, 0302 clinical medicine, 030212 general & internal medicine, Prospective Studies, Rickettsia, Child, bacteria, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Leptospira, Cross Infection, biology, diabetes, Mortality rate, Health Policy, meningitis, 3. Good health, Infectious Diseases, Laos, Child, Preschool, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Ceftriaxone, Female, meningitis/encephalitis, Meningitis, Encephalitis, medicine.drug, Microbiology (medical), Adult, medicine.medical_specialty, patient care management, Asia, Adolescent, medicine.drug_class, viral infections, 030231 tropical medicine, central nervous system infections, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Young Adult, Internal medicine, WHO meningitis, medicine, Humans, lcsh:RC109-216, viruses, antimicrobial medicines, business.industry, Research, lcsh:R, Infant, WHO encephalitis, Japanese encephalitis, medicine.disease, biology.organism_classification, mortality, Japanese encephalitis virus, bacterial infections, Lao, business |
| الوصف: | International audience; During 2003-2011, we recruited 1,065 patients of all ages admitted to Mahosot Hospital (Vientiane, Laos) with suspected central nervous system (CNS) infection. Etiologies were laboratory confirmed for 42.3% of patients, who mostly had infections with emerging pathogens: viruses in 16.2% (mainly Japanese encephalitis virus [8.8%]); bacteria in 16.4% (including Orientia tsutsugamushi [2.9%], Leptospira spp. [2.3%], and Rickettsia spp. [2.3%]); and Cryptococcus spp. fungi in 6.6%. We observed no significant differences in distribution of clinical encephalitis and meningitis by bacterial or viral etiology. However, patients with bacterial CNS infection were more likely to have a history of diabetes than others. Death (26.3%) was associated with low Glasgow Coma Scale score, and the mortality rate was higher for patients with bacterial than viral infections. No clinical or laboratory variables could guide antibiotic selection. We conclude that high-dependency units and first-line treatment with ceftriaxone and doxycycline for suspected CNS infections could improve patient survival in Laos. |
| وصف الملف: | application/pdf; text/pdf |
| اللغة: | English |
| تدمد: | 1080-6040 1080-6059 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5380c78899e7c6120baf82a37256a9c https://www.hal.inserm.fr/inserm-02375431 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e5380c78899e7c6120baf82a37256a9c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10806040 10806059 |
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