Exosomics - A Review Of Biophysics, Biology And Biochemistry Of Exosomes With A Focus On Human Breast Milk
| العنوان: | Exosomics - A Review Of Biophysics, Biology And Biochemistry Of Exosomes With A Focus On Human Breast Milk |
|---|---|
| المؤلفون: | Carolina de la Torre Gomez, Renee V. Goreham, Joan J. Bech Serra, Thomas Nann, Martin Kussmann |
| المصدر: | Recercat. Dipósit de la Recerca de Catalunya instname Frontiers in Genetics, Vol 9 (2018) Frontiers in Genetics Dipòsit Digital de la UB Universidad de Barcelona |
| بيانات النشر: | Frontiers Media Sa |
| مصطلحات موضوعية: | 0301 basic medicine, Proteomics, Breast milk, lcsh:QH426-470, Trace elements in nutrition, Review, Biology, Proteòmica, Exosome, Extracellular vesicles, maternal health, Oligoelements en la nutrició, 03 medical and health sciences, 0302 clinical medicine, proteomics, fluids and secretions, Genetics, exosome, micronutrient, Whole breast, Milk fat globule, Human breast milk, Genetics (clinical), food and beverages, Microvesicles, lcsh:Genetics, 030104 developmental biology, Biochemistry, Llet materna, 030220 oncology & carcinogenesis, Molecular Medicine, breast milk |
| الوصف: | Exosomes are biomolecular nanostructures released from cells. They carry specific biomolecular information and are mainly researched for their exquisite properties as a biomarker source and delivery system. We introduce exosomes in the context of other extracellular vesicles, describe their biophysical isolation and characterisation and discuss their biochemical profiling. Motivated by our interest in early-life nutrition and health, and corresponding studies enrolling lactating mothers and their infants, we zoom into exosomes derived from human breast milk. We argue that these should be more extensively studied at proteomic and micronutrient profiling level, because breast milk exosomes provide a more specific window into breast milk quality from an immunological (proteomics) and nutritional (micronutrient) perspective. Such enhanced breast milk exosome profiling would thereby complement and enrich the more classical whole breast milk analysis and is expected to deliver more functional insights than the rather descriptive analysis of human milk, or larger fractions thereof, such as milk fat globule membrane. We substantiate our arguments by a bioinformatic analysis of two published proteomic data sets of human breast milk exosomes. |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69944dad0f23c7514674d7f22c3af34 http://hdl.handle.net/2445/123988 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e69944dad0f23c7514674d7f22c3af34 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |