التفاصيل البيبلوغرافية
العنوان:
Molecular pathogenesis of disease progression in MLL-rearranged AML
المؤلفون:
Shinichi Kotani , Nobuyuki Kakiuchi , Tetsuichi Yoshizato , Akinori Yoda , June Takeda , Takahiro Maeda , Hiroo Ueno , Yuichi Shiraishi , Cassandra M. Hirsch , Hideki Makishima , Jaroslaw P. Maciejewski , Yusuke Shiozawa , Kenichi Yoshida , Ayana Kon , Seishi Ogawa , Yasuhito Nannya , Masahiro Nakagawa , Yotaro Ochi , Kosuke Aoki , Satoru Miyano , Takuji Yamauchi , Akifumi Takaori-Kondo , Keisuke Kataoka
المصدر:
Leukemia
بيانات النشر:
Nature Publishing Group UK, 2018.
سنة النشر:
2018
مصطلحات موضوعية:
0301 basic medicine , Cancer Research , Myeloid , Oncogene Proteins, Fusion , Clone (cell biology) , Down-Regulation , medicine.disease_cause , Article , 03 medical and health sciences , Mice , 0302 clinical medicine , Downregulation and upregulation , GTP-Binding Proteins , hemic and lymphatic diseases , medicine , Animals , Humans , Exome , neoplasms , Cell Proliferation , Regulation of gene expression , Mutation , business.industry , Gene Expression Regulation, Leukemic , Hematology , Histone-Lysine N-Methyltransferase , medicine.disease , Up-Regulation , PTPN11 , Mice, Inbred C57BL , Leukemia , Leukemia, Myeloid, Acute , 030104 developmental biology , medicine.anatomical_structure , Oncology , 030220 oncology & carcinogenesis , Cancer research , Disease Progression , business , Myeloid-Lymphoid Leukemia Protein
الوصف:
Leukemic relapse is frequently accompanied by progressively aggressive clinical course. To understand the molecular mechanism of leukemic relapse, MLL/AF9-transformed mouse leukemia cells were serially transplanted in C57BL/6 mice (N = 96) by mimicking repeated recurrences, where mutations were monitored by exome sequencing (N = 42). The onset of leukemia was progressively promoted with advanced transplants, during which increasing numbers of somatic mutations were acquired (P
اللغة:
English
تدمد:
1476-5551
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e87676de1d652d7976ea3b5976a972d2 http://europepmc.org/articles/PMC6462875
حقوق:
OPEN
رقم الأكسشن:
edsair.doi.dedup.....e87676de1d652d7976ea3b5976a972d2
قاعدة البيانات:
OpenAIRE
Find this article in full text from Springer Verlag. 