Osteopontin enhances the migration of lung fibroblasts via upregulation of interleukin-6 through the extracellular signal-regulated kinase (ERK) pathway
| العنوان: | Osteopontin enhances the migration of lung fibroblasts via upregulation of interleukin-6 through the extracellular signal-regulated kinase (ERK) pathway |
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| المؤلفون: | Takeshi Uehara, Kazuyuki Matsuda, Yu Fujisawa |
| المصدر: | Biological Chemistry. 401:1071-1080 |
| بيانات النشر: | Walter de Gruyter GmbH, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | MAPK/ERK pathway, MAP Kinase Signaling System, medicine.medical_treatment, Clinical Biochemistry, Transfection, Biochemistry, Idiopathic pulmonary fibrosis, stomatognathic system, Cell Movement, Fibrosis, medicine, Humans, Osteopontin, Extracellular Signal-Regulated MAP Kinases, Interleukin 6, Lung, Molecular Biology, biology, Interleukin-6, Chemistry, Interleukin, Cell migration, Fibroblasts, medicine.disease, Idiopathic Pulmonary Fibrosis, Up-Regulation, Cytokine, biology.protein, Cancer research |
| الوصف: | Fibrosis is a phenomenon in which parenchyma is replaced with fibrous tissue. Persistent inflammation accompanied by dysregulation of cytokine production and repeated cycles of inflammation-associated tissue-repair induces fibrosis in various organs including the liver, lung, and kidney. In idiopathic pulmonary fibrosis, production of interleukin (IL)-6 and osteopontin (OPN) are dysregulated. Fibrosis leads to qualitative rather than quantitative changes of fibroblasts at the sites of tissue repair, and this leads to enlargement of fibrotic foci. These fibroblasts are immunohistochemically positive for OPN; however, the effect of overexpressed OPN in fibroblasts is not fully understood yet. In this study, we investigated the effect of OPN on IL-6 secretion and on migration and proliferation of fibroblasts. Lung fibroblasts overexpressing exogenous OPN showed that OPN was linked to the enhancement of cell migration through increased IL-6 secretion via the extracellular signal-regulated kinase (ERK) pathway. These results suggest that OPN may exert its pro-fibrotic functions, such as enhancement of fibroblasts migration by cooperating with chemoattractant IL-6, and may be involved in enlargement of fibrotic foci. |
| تدمد: | 1437-4315 1431-6730 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e720959869be8fe659f2021ea82337 https://doi.org/10.1515/hsz-2020-0125 |
| رقم الأكسشن: | edsair.doi.dedup.....e9e720959869be8fe659f2021ea82337 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14374315 14316730 |
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