Tissue transglutaminase is involved in the inflammatory processes of active chronic gastritis
| العنوان: | Tissue transglutaminase is involved in the inflammatory processes of active chronic gastritis |
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| المؤلفون: | Pietro Di Giorgio, Raffaele Armentano, Anna Maria Valentini, Giuseppe Riezzo, Antonella Orlando, Benedetta D'Attoma, Antonio Pisani, Francesco Russo, Caterina Clemente |
| المصدر: | Archives of Biological Sciences, Vol 73, Iss 3, Pp 331-339 (2021) |
| بيانات النشر: | National Library of Serbia, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, QH301-705.5, Tissue transglutaminase, Chronic gastritis, Inflammation, Gastroenterology, General Biochemistry, Genetics and Molecular Biology, Pathogenesis, transglutaminase, Internal medicine, medicine, Macrophage, Biology (General), biology, business.industry, Interleukin, medicine.disease, interleukins, inflammation, chronic gastritis, biology.protein, Tumor necrosis factor alpha, Gastritis, medicine.symptom, General Agricultural and Biological Sciences, business |
| الوصف: | Since tissue transglutaminase-2 (TG2) can represent a marker of inflammation for some gastrointestinal (GI) diseases, we aimed to evaluate TG2 and inflammatory markers’ mucosal content in gastric antrum biopsies to shed light on the histological and biochemical background of chronic gastritis inflammation. Fifty-one of 78 patients who underwent upper GI endoscopy (UGIE) for dyspeptic symptoms, had a gastric biopsy. The symptom profile was assessed by a GI symptom rating scale (GSRS) score. Thirtyfive patients (69%) showed chronic gastritis. TG2, interleukin-6 (IL)-6, IL-8, IL-10, tumor necrosis factor (TNF)-α, lipopolysaccharides (LPS) and toll-like receptor (TLR)-4 were evaluated in serum and the culture medium of gastric biopsies. TG2, IL-8, IL-10, TLR-4 and TNF-α were significantly higher in active chronic gastritis than in the inactive one and were linked to macrophage concentration. IL-6 was significantly lower in the active form of chronic gastritis than in the inactive one and negatively correlated with TG2. Lastly, IL- 10 significantly correlated with the macrophage score. TG2 can exert an active role in chronic gastritis pathogenesis by cooperating with different markers of inflammation. It seems that TG2 can represent a possible therapeutic target for modulating inflammation and disease progression. |
| تدمد: | 1821-4339 0354-4664 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5559b5149010d0483cd5a2d4102c8a https://doi.org/10.2298/abs210412026r |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....eb5559b5149010d0483cd5a2d4102c8a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18214339 03544664 |
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