Polymorphisms of p53 codon 72 and MDM2 promoter 309 and the risk of endometrial cancer
| العنوان: | Polymorphisms of p53 codon 72 and MDM2 promoter 309 and the risk of endometrial cancer |
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| المؤلفون: | Naomi Sato, Kiyo Torii, Yoshiaki Okamoto, Eisaku Toji, Sadamu Noda, Masatsugu Ueda, Shinji Izuma, Michiko Yamamoto, Osamu Nunobiki |
| المصدر: | Human Cell. 22:101-106 |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Risk, Cancer Research, Genotype, Single-nucleotide polymorphism, Biology, medicine.disease_cause, Polymorphism, Single Nucleotide, Asian People, medicine, Humans, SNP, Allele, Codon, Promoter Regions, Genetic, Endometrial cancer, Proto-Oncogene Proteins c-mdm2, Cell Biology, Odds ratio, Genes, p53, medicine.disease, Molecular biology, Endometrial Neoplasms, Genotype frequency, Female, Carcinogenesis |
| الوصف: | Genetic polymorphisms of p53 and its negative regulator murine double minute 2 homolog (MDM2) have been shown to be closely associated with tumorigenesis in a variety of human cancers. In the present study, single nucleotide polymorphism (SNP) at p53 codon 72 and MDM2 promoter 309 was examined for germline DNA samples from 102 endometrial cancer cases and 95 controls using polymerase chain reaction-based fragment analysis. There were no significant differences in the genotype and allele prevalence between control subjects and endometrial cancer patients for p53 codon 72. The GG genotype frequency of MDM2-SNP309 was statistically higher in endometrial cancer patients than that in normal healthy women when compared with the TG genotype (P= 0.0088). However, no statistically significant differences were found between the TT and TG or GG genotype frequencies and allele prevalence. Interestingly, the combination of the homozygous Arg/Arg genotype of p53 codon 72 and homozygous GG genotype of MDM2 SNP309 polymorphisms was significantly associated with the risk of endometrial cancer (odds ratio = 3.28, 95% confidence interval = 1.13 to 9.53, P= 0.0212). The homozygous variants of wild p53 codon 72 and mutant MDM2 promoter 309 may cooperatively increase the risk of endometrial cancer in a Japanese population. |
| تدمد: | 1749-0774 0914-7470 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec32b610107b8aa31daa84bbf1edeb6f https://doi.org/10.1111/j.1749-0774.2009.00075.x |
| رقم الأكسشن: | edsair.doi.dedup.....ec32b610107b8aa31daa84bbf1edeb6f |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 17490774 09147470 |
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