Phenolic-antioxidant capacity of mango seed kernels: therapeutic effect against viper venoms
| العنوان: | Phenolic-antioxidant capacity of mango seed kernels: therapeutic effect against viper venoms |
|---|---|
| المؤلفون: | Afaf S. Fahmy, Walaa H. Salama, Mohamed Belal Hamed, Azza M. Abdel-Aty, Saleh A. Mohamed |
| المصدر: | Revista Brasileira de Farmacognosia, Vol 28, Iss 5, Pp 594-601 (2018) Revista Brasileira de Farmacognosia v.28 n.5 2018 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA Revista Brasileira de Farmacognosia, Vol 28, Iss 5, Pp 594-601 Revista Brasileira de Farmacognosia, Volume: 28, Issue: 5, Pages: 594-601, Published: OCT 2018 |
| بيانات النشر: | Elsevier, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Antioxidant, genetic structures, Anti-venom, DPPH, medicine.medical_treatment, lcsh:RS1-441, Viper Venoms, 01 natural sciences, lcsh:Pharmacy and materia medica, Hesperidin, chemistry.chemical_compound, Egyptian mango, 0404 agricultural biotechnology, Hyaluronidase, medicine, Food science, General Pharmacology, Toxicology and Pharmaceutics, Protease, ABTS, biology, 010401 analytical chemistry, food and beverages, 04 agricultural and veterinary sciences, biology.organism_classification, 040401 food science, Phenolic compounds, 0104 chemical sciences, Echis coloratus, chemistry, Oxidative stress, medicine.drug |
| الوصف: | © 2018 Sociedade Brasileira de Farmacognosia In this study, mango seed kernels extract contained a considerable amount of phenolics and flavonoids (17,400 and 3325 mg/100 g seed, respectively). The HPLC profiling revealed that hesperidin was the major phenolic compound of the mango seed kernels extract. This is the first report find hesperidin in mango extracts. The phenolic compounds of mango seed kernels extract were effective in scavenging free radicals of DPPH and ABTS with IC50 values of 47.3 and 7.9 μg/ml, respectively. The total antioxidant activity of mango seed kernels extract based on the reduction of molybdenum was also measured. The phenolic compounds of mango seed kernels extract potentially inhibited the protease, fibrinogenase, phospholipase A2, L-amino acid oxidase, hyaluronidase, and hemolytic activities of the most dangerous Cerastes cerastes and Echis coloratus viper venoms. The phenolic compounds of mango seed kernels extract could completely neutralize the hemorrhage and lethality of both venoms in experimental animals. It could be concluded that the mango seed kernels extract phenolic compounds with potential antioxidant activity are considered as a new avenue in the viper bite treatment. ispartof: Brazilian Journal of Pharmacognosy vol:28 issue:5 pages:594-601 status: published |
| وصف الملف: | text/html |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9e62ef56512587602ab8e66106d475 http://www.sciencedirect.com/science/article/pii/S0102695X18301480 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ec9e62ef56512587602ab8e66106d475 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |