Chimeric antigen receptor T-cell therapy beyond cancer: current practice and future prospects
| العنوان: | Chimeric antigen receptor T-cell therapy beyond cancer: current practice and future prospects |
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| المؤلفون: | Qiu Li, Dan Xie, Peng-Fei Zhang |
| المصدر: | Immunotherapy. 12:1021-1034 |
| بيانات النشر: | Future Medicine Ltd, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Graft Rejection, 0301 basic medicine, medicine.medical_treatment, Immunology, Receptors, Antigen, T-Cell, Disease, Communicable Diseases, Immunotherapy, Adoptive, Autoimmune Diseases, Cell therapy, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, medicine, Humans, Immunology and Allergy, Receptors, Chimeric Antigen, business.industry, Autoantibody, Cancer, medicine.disease, Chimeric antigen receptor, 030104 developmental biology, Oncology, Current practice, 030220 oncology & carcinogenesis, Cancer research, Chimeric Antigen Receptor T-Cell Therapy, business, human activities, Allotransplantation |
| الوصف: | Adoptive cell therapy with chimeric antigen receptor T (CAR-T) cells has achieved remarkable efficacy in the treatment of hematological malignancies, which has inspired researchers to expand the application of CAR-T-cell therapy to other medical conditions. Here, we review the current understanding and development of CAR-T-cell therapy for infectious diseases, autoimmune diseases and allotransplantation. The limitations and challenges of CAR-T-cell therapy in the treatment of these diseases and potential solutions to overcome these shortcomings are also discussed. With the development of novel designs of CARs and preclinical/clinical investigations, CAR-T-cell therapy is expected to be a potential cure option in a wide array of disease settings in the future. |
| تدمد: | 1750-7448 1750-743X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb856e315b96cd71ea7b8ec426eb300 https://doi.org/10.2217/imt-2020-0009 |
| رقم الأكسشن: | edsair.doi.dedup.....edb856e315b96cd71ea7b8ec426eb300 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17507448 1750743X |
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