FDXR is a biomarker of radiation exposure in vivo
| العنوان: | FDXR is a biomarker of radiation exposure in vivo |
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| المؤلفون: | Edward W. Green, Jakub Grepl, Grainne O’Brien, Aleš Tichý, Ellen M. Donovan, Navita Somaiah, Fergus V. Gleeson, Lucyna Ponge, Lone Gothard, Matthias Port, Christophe Badie, Mahesh Kudari, Igor Sirák, Krzysztof Slosarek, Volodymyr A. Vinnikov, Leonid Vasyliev, Sergii Artiukh, Viktor Starenkiy, Matthäus Majewski, Leszek Miszczyk, Lourdes Cruz-Garcia, Elizabeth A. Ainsbury, Sue Boyle, Michael Abend, Azfar Zaman, Neel Patel, Andrea Malkova, Piotr Widlak |
| المصدر: | Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018) Scientific Reports |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Lipopolysaccharides, Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Curcumin, medicine.medical_treatment, lcsh:Medicine, Article, Ionizing radiation, Young Adult, 03 medical and health sciences, 0302 clinical medicine, In vivo, Neoplasms, Internal medicine, Humans, Medicine, lcsh:Science, Aged, Aged, 80 and over, Multidisciplinary, business.industry, lcsh:R, Confounding, Total body, Middle Aged, Up-Regulation, 3. Good health, Ferredoxin-NADP Reductase, Radiation therapy, Radiation exposure, 030104 developmental biology, 030220 oncology & carcinogenesis, RNA, Biomarker (medicine), Female, lcsh:Q, Tomography, X-Ray Computed, business, Biomarkers, Whole-Body Irradiation, Ex vivo |
| الوصف: | Previous investigations in gene expression changes in blood after radiation exposure have highlighted its potential to provide biomarkers of exposure. Here, FDXR transcriptional changes in blood were investigated in humans undergoing a range of external radiation exposure procedures covering several orders of magnitude (cardiac fluoroscopy, diagnostic computed tomography (CT)) and treatments (total body and local radiotherapy). Moreover, a method was developed to assess the dose to the blood using physical exposure parameters. FDXR expression was significantly up-regulated 24 hr after radiotherapy in most patients and continuously during the fractionated treatment. Significance was reached even after diagnostic CT 2 hours post-exposure. We further showed that no significant differences in expression were found between ex vivo and in vivo samples from the same patients. Moreover, potential confounding factors such as gender, infection status and anti-oxidants only affect moderately FDXR transcription. Finally, we provided a first in vivo dose-response showing dose-dependency even for very low doses or partial body exposure showing good correlation between physically and biologically assessed doses. In conclusion, we report the remarkable responsiveness of FDXR to ionising radiation at the transcriptional level which, when measured in the right time window, provides accurate in vivo dose estimates. |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee2897befbd1b27586ff9bd8f8e91ff1 https://doi.org/10.1038/s41598-017-19043-w |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ee2897befbd1b27586ff9bd8f8e91ff1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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