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Low-dose dual-isotope procedure planed for myocardial perfusion CZT-SPECT and assessed through a head-to-head comparison with a conventional single-isotope protocol

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العنوان: Low-dose dual-isotope procedure planed for myocardial perfusion CZT-SPECT and assessed through a head-to-head comparison with a conventional single-isotope protocol
المؤلفون: Gilles Karcher, Charles Merlin, Véronique Roch, Laetitia Imbert, Florent Cachin, Pierre-Yves Marie, Wassila Djaballah, Antoine Verger, Marine Claudin, Mathieu Perrin, Henri Boutley
المساهمون: Service de Médecine Nucléaire [Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Nancyclotep- Experimental Imaging Platform = Plate-forme d'imagerie moléculaire, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Université de Lorraine (UL), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] (UNICANCER/ICL), UNICANCER, Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), Imagerie Moléculaire et Thérapie Vectorisée (IMTV), Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Cancéropôle CLARA-ITMO ' Technologies pour la Santé ', Université de Lorraine (UL), Faculté de Médecine [Nancy], Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), ITMO ' Technologies pour la Santé '-Cancéropôle CLARA-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université d'Auvergne - Clermont-Ferrand I (UdA), Service de Médecine Nucléaire [CHRU Nancy]
المصدر: Journal of Nuclear Cardiology
Journal of Nuclear Cardiology, Springer Verlag, 2017, 25 (6), pp.2016-2023. ⟨10.1007/s12350-017-0914-z⟩
Journal of Nuclear Cardiology, 2017, 25 (6), pp.2016-2023. ⟨10.1007/s12350-017-0914-z⟩
بيانات النشر: Springer Science and Business Media LLC, 2017.
سنة النشر: 2017
مصطلحات موضوعية: Technetium Tc 99m Sestamibi, medicine.medical_specialty, dual-isotope protocol, Sestamibi, 030204 cardiovascular system & hematology, Single-photon emission computed tomography, Radiation Dosage, Effective dose (radiation), 030218 nuclear medicine & medical imaging, Isotopes of technetium, 03 medical and health sciences, Myocardial perfusion imaging, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Technetium-99, CZT camera, medicine, Humans, Radiology, Nuclear Medicine and imaging, Tomography, Emission-Computed, Single-Photon, medicine.diagnostic_test, business.industry, Thallium Radioisotopes, Zinc, thallium-201, Tomography, Radiology, Radiopharmaceuticals, Tellurium, Cardiology and Cardiovascular Medicine, business, Nuclear medicine, Perfusion, Emission computed tomography, Cadmium
الوصف: International audience; Purpose of the report: This study aimed at assessing an original low-dose dual-isotope procedure in which the abnormal stress Tc-99m Sestamibi SPECT is followed by rest Tl-201 SPECT, along with a head-to-head comparison with a single-isotope procedure.Methods and results: One hundred two patients, referred for a low-dose stress-SPECT with Sestamibi (123 ± 20 MBq) on a CZT camera and for whom a rest Sestamibi SPECT was warranted, had an additional Tl-201 rest-SPECT (52 ± 5 MBq) between stress and rest Sestamibi SPECT recordings. Tl-201 images were processed for spill-over and scatter corrections, and uptake differences with stress Sestamibi SPECT were analyzed: (1) for rest acquisitions from Tl-201 (dual-isotope procedure) and from Sestamibi (single-isotope procedure) and (2) in segments for which a diagnosis of ischemia, infarct, or normal perfusion was achieved. Mean effective dose was 8.3 mSv for dual-isotope but would decrease to 5.7 mSv for an expected rate of 37% of patients for whom rest-SPECT is not warranted. After a further background correction of Tl-201 images, the rest-stress difference in myocardial uptake was equivalent between dual- and single-procedures for identifying ischemic segments (respective areas-under-curves: 0.83 ± 0.03 and 0.81 ± 0.03).Conclusion: This original dual-isotope procedure provides acceptable radiation doses and consistent results, as compared with conventional single-isotope.
تدمد: 1532-6551
1071-3581
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eecf5a7db679cb59eb70f08e9b2af210
https://doi.org/10.1007/s12350-017-0914-z
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....eecf5a7db679cb59eb70f08e9b2af210
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15326551
10713581