Telomere repeats induce domains of H3K27 methylation in Neurospora
| العنوان: | Telomere repeats induce domains of H3K27 methylation in Neurospora |
|---|---|
| المؤلفون: | Kirsty Jamieson, Eric U. Selker, Shinji Honda, Tereza Ormsby, Neena A. Leggett, Kevin J McNaught |
| المصدر: | eLife, Vol 7 (2018) eLife |
| بيانات النشر: | Cold Spring Harbor Laboratory, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, QH301-705.5, Heterochromatin, Science, Methylation, polycomb repressive complex 2, Neurospora, General Biochemistry, Genetics and Molecular Biology, Neurospora crassa, Histones, 03 medical and health sciences, Histone H3, position effect, 0302 clinical medicine, Gene Expression Regulation, Fungal, Constitutive heterochromatin, Biology (General), Repetitive Sequences, Nucleic Acid, 030304 developmental biology, Genomic organization, Genetics, H3K27, 0303 health sciences, General Immunology and Microbiology, biology, General Neuroscience, fungi, N. crassa, General Medicine, Telomere, biology.organism_classification, Subtelomere, chromosome rearrangements, telomere repeats, 030104 developmental biology, Position effect, Histone, Genes and Chromosomes, biology.protein, Medicine, Protein Processing, Post-Translational, 030217 neurology & neurosurgery, Research Article |
| الوصف: | Development in higher organisms requires selective gene silencing, directed in part by di-/tri-methylation of lysine 27 on histone H3 (H3K27me2/3). Knowledge of the cues that control formation of such repressive Polycomb domains is extremely limited. We exploited natural and engineered chromosomal rearrangements in the fungusNeurospora crassato elucidate the control of H3K27me2/3. Analyses of H3K27me2/3 in strains bearing chromosomal rearrangements revealed both position-dependent and position-independent facultative heterochromatin. We found that proximity to chromosome ends is necessary to maintain, and sufficient to induce, transcriptionally repressive, subtelomeric H3K27me2/3. We ascertained that such telomere-proximal facultative heterochromatin requires native telomere repeats and found that a short array of ectopic telomere repeats, (TTAGGG)17, can induce a large domain (∼225 kb) of H3K27me2/3. This provides an example of acis-acting sequence that directs H3K27 methylation. Our findings provide new insight into the relationship between genome organization and control of heterochromatin formation. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ad8e4b49cd12318ba6952528205740 https://doi.org/10.1101/189258 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f0ad8e4b49cd12318ba6952528205740 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |