Modulating the Gut Microbiota Improves Glucose Tolerance, Lipoprotein Profile and Atherosclerotic Plaque Development in ApoE-Deficient Mice
العنوان: | Modulating the Gut Microbiota Improves Glucose Tolerance, Lipoprotein Profile and Atherosclerotic Plaque Development in ApoE-Deficient Mice |
---|---|
المؤلفون: | Jenny E. Kanter, Johannes Josef Fels, Bidda Rolin, Ida Rune, Karin E. Bornfeldt, Pernille Kihl, Christian P. Larsen, Karsten Buschard, Dennis Sandris Nielsen, Axel Kornerup Hansen, Jens Lykkesfeldt, Knud Josefsen, Rikke Kaae Kirk, Berit Ø Christoffersen |
المصدر: | PLoS ONE Rune, I, Rolin, B, Larsen, C S, Nielsen, D S, Kanter, J E, Bornfeldt, K E, Lykkesfeldt, J, Buschard, K, Kirk, R K, Christoffersen, B, Fels, J J, Josefsen, K, Kihl, P & Hansen, A K 2016, ' Modulating the gut microbiota improves glucose tolerance, lipoprotein profile and atherosclerotic plaque development in ApoE-deficient mice ', P L o S One, vol. 11, no. 1, e0146439 . https://doi.org/10.1371/journal.pone.0146439 PLoS ONE, Vol 11, Iss 1, p e0146439 (2016) |
سنة النشر: | 2014 |
مصطلحات موضوعية: | 0301 basic medicine, Apolipoprotein E, Very low-density lipoprotein, Apolipoprotein B, medicine.medical_treatment, lcsh:Medicine, Gut flora, Lipoproteins, VLDL, Pathology and Laboratory Medicine, Vascular Medicine, Biochemistry, Gliadin, chemistry.chemical_compound, Mice, 0302 clinical medicine, Endocrinology, Medicine and Health Sciences, Insulin, lcsh:Science, Immune Response, Glucose Tolerance, 2. Zero hunger, Mice, Knockout, Multidisciplinary, Animal Models, Lipids, Plaque, Atherosclerotic, 3. Good health, Lipoproteins, LDL, Cholesterol, Cardiovascular Diseases, Research Article, medicine.medical_specialty, Immunology, Mouse Models, Biology, Diet, High-Fat, Research and Analysis Methods, 03 medical and health sciences, Diet, Gluten-Free, Apolipoproteins E, Model Organisms, Signs and Symptoms, Internal medicine, medicine, Animals, Nutrition, Diabetic Endocrinology, Inflammation, lcsh:R, nutritional and metabolic diseases, Biology and Life Sciences, Proteins, biology.organism_classification, Atherosclerosis, Hormones, Gastrointestinal Microbiome, Diet, Mice, Inbred C57BL, 030104 developmental biology, Glucose, Metabolism, chemistry, biology.protein, lcsh:Q, Gluten free, Ampicillin, 030217 neurology & neurosurgery, Gluten, Lipoprotein |
الوصف: | The importance of the gut microbiota (GM) in disease development has recently received increased attention, and numerous approaches have been made to better understand this important interplay. For example, metabolites derived from the GM have been shown to promote atherosclerosis, the underlying cause of cardiovascular disease (CVD), and to increase CVD risk factors. Popular interest in the role of the intestine in a variety of disease states has now resulted in a significant proportion of individuals without coeliac disease switching to gluten-free diets. The effect of gluten-free diets on atherosclerosis and cardiovascular risk factors is largely unknown. We therefore investigated the effect of a gluten-free high-fat cholesterol-rich diet, as compared to the same diet in which the gluten peptide gliadin had been added back, on atherosclerosis and several cardiovascular risk factors in apolipoprotein E-deficient (Apoe-/-) mice. The gluten-free diet transiently altered GM composition in these mice, as compared to the gliadin-supplemented diet, but did not alter body weights, glucose tolerance, insulin levels, plasma lipids, or atherosclerosis. In parallel, other Apoe-/- mice fed the same diets were treated with ampicillin, a broad-spectrum antibiotic known to affect GM composition. Ampicillin-treatment had a marked and sustained effect on GM composition, as expected. Furthermore, although ampicillin-treated mice were slightly heavier than controls, ampicillin-treatment transiently improved glucose tolerance both in the absence or presence of gliadin, reduced plasma LDL and VLDL cholesterol levels, and reduced aortic atherosclerotic lesion area. These results demonstrate that a gluten-free diet does not seem to have beneficial effects on atherosclerosis or several CVD risk factors in this mouse model, but that sustained alteration of GM composition with a broad-spectrum antibiotic has beneficial effects on CVD risk factors and atherosclerosis. These findings support the concept that altering the microbiota might provide novel treatment strategies for CVD. |
وصف الملف: | application/pdf |
تدمد: | 1932-6203 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10d39b1a77eb1f6af78d26a8f85697b https://pubmed.ncbi.nlm.nih.gov/26799618 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....f10d39b1a77eb1f6af78d26a8f85697b |
قاعدة البيانات: | OpenAIRE |
تدمد: | 19326203 |
---|