The Matrikine Acetylated Proline-Glycine-Proline Couples Vascular Inflammation and Acute Cardiac Rejection
| العنوان: | The Matrikine Acetylated Proline-Glycine-Proline Couples Vascular Inflammation and Acute Cardiac Rejection |
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| المؤلفون: | Amit Gaggar, Gregory A. Payne, Xin Xu, Hongwei Qin, J. Michael Wells, Jindong Li, Massoud A. Leesar, Rakesh P. Patel, Suzanne Oparil, Patricia L. Jackson, David M. Pollock, J. Edwin Blalock |
| المصدر: | Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017) Scientific Reports |
| بيانات النشر: | Nature Portfolio, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Graft Rejection, Male, Vasculitis, Chemokine, Proline, Science, Matrix (biology), Receptors, Interleukin-8B, Article, Extracellular matrix, 03 medical and health sciences, Mediator, In vivo, Medicine, Humans, CXC chemokine receptors, Multidisciplinary, biology, Endothelin-1, business.industry, Vascular disease, Middle Aged, medicine.disease, In vitro, 3. Good health, Extracellular Matrix, 030104 developmental biology, Immunology, Cancer research, biology.protein, Heart Transplantation, Female, Chemokines, business, Oligopeptides |
| الوصف: | The extracellular matrix (ECM) is a dynamic, bioactive structure critical to organ development, structure and function. Excessive remodeling of the ECM is a hallmark of a variety of inflammatory conditions including vascular disease. Endothelin-1 (ET1) synthesis is understood to promote cardiovascular diseases including acute cardiac transplant rejection; however, the contribution of ECM-derived chemokines (matrikines) to vascular inflammation remains poorly understood. Herein we report that the matrikine acetylated Pro-Gly-Pro (PGP) stimulates vascular inflammation through activation of endothelial CXC Chemokine Receptor 2 (CXCR2) and production of endothelin-1 both in vitro and in vivo. As a proof of hypothesis, we demonstrate that coronary PGP levels associate with both circulating endothelin-1 and acute rejection in cardiac transplant patients (sensitivity of 100% and specificity of 86%). These findings establish PGP as a novel mediator in cardiovascular disease, and implicate bioactive matrix fragments as underappreciated agents potentially active in numerous conditions propagated by progressive vascular inflammation. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f198ce4cecb720c17fcd1bedcb87269e https://doaj.org/article/a02a41bb53f14b3b8aaea863666146da |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f198ce4cecb720c17fcd1bedcb87269e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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