Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice
| العنوان: | Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice |
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| المؤلفون: | Munehiro Ohashi, Satoshi Teramukai, Ryutaro Ono, Akihiro Shimba, Yoichi Minami, Yasuhiro Umemura, Kazuhiro Yagita, Koichi Ikuta, Eiryo Kawakami, Guangwei Cui, Nobuya Koike, Takuma Asahi, Eiichi Konishi, Yuh Sasawaki, Zheng Chen, Yoshiki Tsuchiya, Hitoshi Inokawa, Seung Hee Yoo |
| المصدر: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020) |
| بيانات النشر: | Nature Publishing Group UK, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, T-Lymphocytes, Longevity, Programmed Cell Death 1 Receptor, lcsh:Medicine, Inflammation, Endogeny, Biology, Article, Transcriptome, 03 medical and health sciences, Mice, 0302 clinical medicine, Immune system, medicine, Mesenteric lymph nodes, Animals, Humans, Circadian rhythm, lcsh:Science, Transcriptomics, Cellular Senescence, Jet Lag Syndrome, B-Lymphocytes, Multidisciplinary, Sequence Analysis, RNA, lcsh:R, Germinal center, medicine.disease, Circadian Rhythm, Ageing, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Hyaluronan Receptors, Immunology, lcsh:Q, medicine.symptom, Steatohepatitis, 030217 neurology & neurosurgery |
| الوصف: | Modern society characterized by a 24/7 lifestyle leads to misalignment between environmental cycles and endogenous circadian rhythms. Persisting circadian misalignment leads to deleterious effects on health and healthspan. However, the underlying mechanism remains not fully understood. Here, we subjected adult, wild-type mice to distinct chronic jet-lag paradigms, which showed that long-term circadian misalignment induced significant early mortality. Non-biased RNA sequencing analysis using liver and kidney showed marked activation of gene regulatory pathways associated with the immune system and immune disease in both organs. In accordance, we observed enhanced steatohepatitis with infiltration of inflammatory cells. The investigation of senescence-associated immune cell subsets from the spleens and mesenteric lymph nodes revealed an increase in PD-1+CD44high CD4 T cells as well as CD95+GL7+ germinal center B cells, indicating that the long-term circadian misalignment exacerbates immune senescence and consequent chronic inflammation. Our results underscore immune homeostasis as a pivotal interventional target against clock-related disorders. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f268aa7c712c01d6426ec2fb316a670f http://europepmc.org/articles/PMC7018741 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f268aa7c712c01d6426ec2fb316a670f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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