COVID ‐19: Recovery from Chemosensory Dysfunction. A Multicentre study on Smell and Taste
| العنوان: | COVID ‐19: Recovery from Chemosensory Dysfunction. A Multicentre study on Smell and Taste |
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| المؤلفون: | Julia Draf, Aytug Altundag, Eleonora Maria Consiglia Trecca, Constantin Hintschich, Andreas Steenholt Niklassen, Ludger Klimek, Caroline Huart, Simone Bocksberger, Thomas Hummel, Serge D Le Bon |
| المساهمون: | UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'oto-rhino-laryngologie, Tıp Fakültesi |
| المصدر: | The Laryngoscope Niklassen, A S, Draf, J, Huart, C, Hintschich, C, Bocksberger, S, Trecca, E M C, Klimek, L, Le Bon, S D, Altundag, A & Hummel, T 2021, ' COVID-19 : Recovery from Chemosensory Dysfunction. A Multicentre study on Smell and Taste ', The Laryngoscope, vol. 131, no. 5, pp. 1095-1100 . https://doi.org/10.1002/lary.29383 The Laryngoscope, Vol. 131, no. 5, p. 1095-1100 (2021) |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Olfactory system, Taste, medicine.medical_specialty, Olfactory Perception/physiology, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Disease, Audiology, Olfaction Disorders, Taste Disorders, 03 medical and health sciences, 0302 clinical medicine, SARS-CoV-2/genetics, Psychophysics, Humans, Medicine, Prospective Studies, 030223 otorhinolaryngology, Prospective cohort study, Infection only, COVID-19 Smell Taste Recovery Psychophysical, COVID-19 smell taste recovery psychophysical, SARS-CoV-2, business.industry, Psychophysics/methods, Significant difference, COVID-19, Taste Perception, Recovery of Function, Middle Aged, Olfactory Perception, Recovery of Function/physiology, Otorhinolaryngology, Taste Disorders/physiopathology, Olfaction Disorders/physiopathology, Taste Perception/physiology, COVID-19/complications, Female, business, 030217 neurology & neurosurgery |
| الوصف: | OBJECTIVE/HYPOTHESIS With the COVID-19 pandemic, chemosensory dysfunction are among the most prevalent symptoms. Most reports are subjective evaluations, which have been suggested to be unreliable. The objective is to test chemosensory dysfunction and recovery based on extensive psychophysical tests in COVID-19 during the course of the disease. STUDY DESIGN Prospective cohort study. METHODS A total of 111 patients from four centers participated in the study. All tested positive for SARS-COV-2 with RT-PCR. They were tested within 3 days of diagnosis and 28 to 169 days after infection. Testing included extensive olfactory testing with the Sniffin' Sticks test for threshold, discrimination and identification abilities, and with the Taste Sprays and Taste Strips for gustatory function for quasi-threshold and taste identification abilities. RESULTS There was a significant difference in olfactory function during and after infection. During infection 21% were anosmic, 49% hyposmic, and 30% normosmic. After infection only 1% were anosmic, 26% hyposmic, and 73% normosmic. For gustatory function, there was a difference for all taste qualities, but significantly in sour, bitter, and total score. Twenty-six percent had gustatory dysfunction during infection and 6.5% had gustatory dysfunction after infection. Combining all tests 22% had combined olfactory and gustatory dysfunction during infection. After infection no patients had combined dysfunction. CONCLUSIONS Chemosensory dysfunction is very common in COVID-19, either as isolated smell or taste dysfunction or a combined dysfunction. Most people regain their chemosensory function within the first 28 days, but a quarter of the patients show persisting dysfunction, which should be referred to specialist smell and taste clinics for rehabilitation of chemosensory function. LEVEL OF EVIDENCE 3 Laryngoscope, 131:1095-1100, 2021. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1531-4995 0023-852X |
| DOI: | 10.1002/lary.29383 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f384d0d8b13b60f1c805c670b6fb244d |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f384d0d8b13b60f1c805c670b6fb244d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15314995 0023852X |
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| DOI: | 10.1002/lary.29383 |