MAPK and PI3K signaling: At the crossroads of neural crest development
| العنوان: | MAPK and PI3K signaling: At the crossroads of neural crest development |
|---|---|
| المؤلفون: | Colin J. Dinsmore, Philippe Soriano |
| المصدر: | Developmental biology. 444 |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, MAPK/ERK pathway, Cell signaling, MAP Kinase Signaling System, medicine.medical_treatment, Neurogenesis, Receptor tyrosine kinase, Article, 03 medical and health sciences, Phosphatidylinositol 3-Kinases, Cell Movement, medicine, Animals, Humans, Phosphorylation, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Body Patterning, biology, Growth factor, Neural crest, Cell Differentiation, Cell Biology, Protein-Tyrosine Kinases, Biological Evolution, ErbB Receptors, 030104 developmental biology, Neural Crest, Vertebrates, biology.protein, Signal transduction, Mitogen-Activated Protein Kinases, Neuroscience, Proto-Oncogene Proteins c-akt, Developmental Biology, Signal Transduction |
| الوصف: | Receptor tyrosine kinase-mediated growth factor signaling is essential for proper formation and development of the neural crest. The many ligands and receptors implicated in these processes signal through relatively few downstream pathways, frequently converging on the MAPK and PI3K pathways. Despite decades of study, there is still considerable uncertainty about where and when these signaling pathways are required and how they elicit particular responses. This review summarizes our current understanding of growth factor-induced MAPK and PI3K signaling in the neural crest. |
| تدمد: | 1095-564X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f394986e75a1dc485e2b84e225c96bd6 https://pubmed.ncbi.nlm.nih.gov/29453943 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f394986e75a1dc485e2b84e225c96bd6 |
| قاعدة البيانات: | OpenAIRE |
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