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Longitudinal predictors of bronchial hyperresponsiveness and FEV1 decline in bakers

التفاصيل البيبلوغرافية
العنوان: Longitudinal predictors of bronchial hyperresponsiveness and FEV1 decline in bakers
المؤلفون: Michel Grzebyk, N. Massin, M. Hery, Pascal Wild, Christophe Paris, Valérie Demange
المساهمون: Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) (INRS ( Vandoeuvre lès Nancy)), CHU Pontchaillou [Rennes], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), INRS, Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Chard-Hutchinson, Xavier
المصدر: International Archives of Occupational and Environmental Health
International Archives of Occupational and Environmental Health, Springer Verlag, 2021, 94 (4), pp.751-761. ⟨10.1007/s00420-020-01628-0⟩
International Archives of Occupational and Environmental Health, 2021, 94 (4), pp.751-761. ⟨10.1007/s00420-020-01628-0⟩
بيانات النشر: HAL CCSD, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Spirometry, medicine.medical_specialty, Longitudinal study, Bakers, Epidemiology, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, [SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health, 030212 general & internal medicine, Respiratory health, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, medicine.diagnostic_test, business.industry, Public Health, Environmental and Occupational Health, Occupational exposure, medicine.disease, 030210 environmental & occupational health, Lung function, respiratory tract diseases, Bronchial hyperresponsiveness, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Mixed effects, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Methacholine, Bronchial challenge test, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, medicine.drug
الوصف: International audience; Objective To determine long-term predictors of bronchial hyperresponsiveness (BHR) and forced expiratory volume in one second (FEV1) decline.Methods A longitudinal study in 110 bakers in 4 industrial bakeries and 38 non-exposed workers was conducted at the workplace with a mean of 3.3 visits per subject over a period of 13 years and a mean duration of follow-up of 6 years in bakers and 8 years in non-exposed subjects. A respiratory health questionnaire was administered; occupational allergen skin prick tests, spirometry and a methacholine bronchial challenge test were performed at each visit. In each bakery, full-shift dust samples of the inhalable fraction were obtained in order to assess the exposure of each job assignment. The repeated measurements of BHR and FEV1 were analyzed using mixed effects logistic and linear regression models in subjects seen at least twice.Results BHR, respiratory symptoms and their simultaneous occurrence depended on the duration of exposure. FEV1 significantly decreased with duration of exposure and BHR at a preceding visit. This result persisted when adjusting for the effect of BHR at the current visit. The measured exposure levels were not a significant predictor for any outcome. Occupational sensitization was only a predictor of a decline in FEV1 when duration of exposure was not included.Conclusion In flour-exposed industrial bakers, length of exposure and smoking are long-term determinants of BHR and of the decrease in FEV1. BHR at a preceding visit predicted lower FEV1 even when accounting for the effect of BHR at the current visit.
وصف الملف: application/pdf
اللغة: English
تدمد: 0340-0131
1432-1246
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40bcbec5e5ec8a5b46ecc111d39b70d
https://hal.archives-ouvertes.fr/hal-03131173
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....f40bcbec5e5ec8a5b46ecc111d39b70d
قاعدة البيانات: OpenAIRE
الوصف
تدمد:03400131
14321246