SSRIs: Applications in inflammatory lung disease and implications for COVID‐19
| العنوان: | SSRIs: Applications in inflammatory lung disease and implications for COVID‐19 |
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| المؤلفون: | Randall G. Worth, Cheryl B. McCullumsmith, Justin F. Creeden, Claire K. Meikle |
| المصدر: | Neuropsychopharmacology Reports |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | ARDS, Anti-Inflammatory Agents, Inflammation, Review Article, Proinflammatory cytokine, Pathogenesis, chemistry.chemical_compound, COVID‐19, medicine, Humans, Pharmacology (medical), STAT3, Review Articles, Pharmacology, COPD, selective serotonin reuptake inhibitor, Lung, biology, SARS-CoV-2, business.industry, lung inflammation, NF‐κB, COVID-19, NF-κB, Pneumonia, medicine.disease, Psychiatry and Mental health, Clinical Psychology, medicine.anatomical_structure, chemistry, Immunology, biology.protein, medicine.symptom, business, Selective Serotonin Reuptake Inhibitors |
| الوصف: | Selective serotonin reuptake inhibitors (SSRIs) have anti‐inflammatory properties that may have clinical utility in treating severe pulmonary manifestations of COVID‐19. SSRIs exert anti‐inflammatory effects at three mechanistic levels: (a) inhibition of proinflammatory transcription factor activity, including NF‐κB and STAT3; (b) downregulation of lung tissue damage and proinflammatory cell recruitment via inhibition of cytokines, including IL‐6, IL‐8, TNF‐α, and IL‐1β; and (c) direct suppression inflammatory cells, including T cells, macrophages, and platelets. These pathways are implicated in the pathogenesis of COVID‐19. In this review, we will compare the pathogenesis of lung inflammation in pulmonary diseases including COVID‐19, ARDS, and chronic obstructive pulmonary disease (COPD), describe the anti‐inflammatory properties of SSRIs, and discuss the applications of SSRIS in treating COVID‐19‐associated inflammatory lung disease. Selective serotonin reuptake inhibitors (SSRIs) have anti‐inflammatory effects on transcription factor activity, cytokine expression profiles, and suppression of innate and adaptive immune cells. These anti‐inflammatory properties may be useful in treating pulmonary inflammation, especially in the case of COVID‐19. |
| تدمد: | 2574-173X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75beb9debab31ed61d71c746939cc41 https://doi.org/10.1002/npr2.12194 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f75beb9debab31ed61d71c746939cc41 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2574173X |
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