Effect of Mineralocorticoid Receptor Blockade on Arterial Stiffness and Endothelial Function
| العنوان: | Effect of Mineralocorticoid Receptor Blockade on Arterial Stiffness and Endothelial Function |
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| المؤلفون: | Tetsutaro Matayoshi, Hisatomi Arima, Atsushi Sakima, Yusuke Ohya, Akio Ishida |
| المصدر: | Hypertension. 77:929-937 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Blood Pressure, Pulse Wave Analysis, law.invention, Vascular Stiffness, Mineralocorticoid receptor, Randomized controlled trial, law, Internal medicine, Outcome Assessment, Health Care, Internal Medicine, medicine, Humans, cardiovascular diseases, Endothelial dysfunction, Pulse wave velocity, Mineralocorticoid Receptor Antagonists, Randomized Controlled Trials as Topic, business.industry, medicine.disease, Blockade, Receptors, Mineralocorticoid, Blood pressure, Cardiovascular Diseases, Meta-analysis, cardiovascular system, Arterial stiffness, Cardiology, Endothelium, Vascular, business, circulatory and respiratory physiology |
| الوصف: | Although numerous studies have confirmed the beneficial effects of pharmacological therapy for arterial stiffness and endothelial dysfunction, which are predictors/therapeutic targets for cardiovascular diseases, only a few overall quantitative evaluations of MRAs (mineralocorticoid receptor antagonists) exist. We searched PubMed and Cochrane CENTRAL (Cochrane Central Register of Controlled Trials) for randomized trials evaluating MRA effects on arterial stiffness measured by pulse wave velocity (PWV) or augmentation index and endothelial function measured by flow-mediated dilation. Data from the included trials were pooled by using random-effects meta-analysis of the weighted mean difference (MD) between the comparator groups. The primary outcome was the MD of PWV. In 11 trials including 515 patients, the MRA treatment reduced the PWV when compared with control (MD, −0.75 m/s [95% CI, −1.12 to −0.39], P P =0.705 for heterogeneity). The effects of MRA on PWV were independent of blood pressure reduction related to the treatment according to meta-regression analysis. The MRA treatment reduced the augmentation index compared with control in 5 trials including 283 patients (MD, −6.74% [95% CI, −10.26 to −3.21], P =0.0002) and increased the flow-mediated dilation in 11 trials including 570 patients (MD, 1.18% [95% CI, 0.14 to 2.23], P =0.03). In conclusion, the current meta-analysis demonstrates the beneficial effects of MRA on PWV, augmentation index, and flow-mediated dilation. |
| تدمد: | 1524-4563 0194-911X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f833d8fa5bd351089d3e423d974ff853 https://doi.org/10.1161/hypertensionaha.120.16397 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f833d8fa5bd351089d3e423d974ff853 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244563 0194911X |
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