Role of HLA-DQ typing and antitissue transglutaminase antibody titres in diagnosing coeliac disease among Sudanese children with type 1 diabetes mellitus
| العنوان: | Role of HLA-DQ typing and antitissue transglutaminase antibody titres in diagnosing coeliac disease among Sudanese children with type 1 diabetes mellitus |
|---|---|
| المؤلفون: | Ibtihag Ibaid, Mohammed Hussien, Katri Kaukinen, Omayma Sabir, Miskelyemen Elmekki, Azza Musa, Nasreldein Abdelhadi, Abdel Rahim El Hussein, Päivi Saavalainen |
| المساهمون: | Tampere University, Department of Internal medicine, Clinical Medicine, TRIMM - Translational Immunology Research Program, Immunomics, Department of Medical and Clinical Genetics |
| المصدر: | BMJ Open Gastroenterology, Vol 9, Iss 1 (2022) BMJ Open Gastroenterology |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | musculoskeletal diseases, Adolescent, Coeliac Disease, RC799-869, 3121 Internal medicine, paediatric gastroenterology, Sudan, Young Adult, HLA-DQ Antigens, Humans, Child, Autoantibodies, Transglutaminases, CLINICAL-FEATURES, Gastroenterology, Infant, Diseases of the digestive system. Gastroenterology, PREVALENCE, Immunoglobulin A, Celiac Disease, Diabetes Mellitus, Type 1, nutrition, 3121 General medicine, internal medicine and other clinical medicine, Child, Preschool, BIOPSY, LIBYAN CHILDREN |
| الوصف: | ObjectiveThe aim of the study was to determine the prevalence of coeliac disease (CD) and to recognise Human leukocyte antigen (HLA)-associated hereditary susceptibility to Sudanese CD patients with type 1 diabetes mellitus (DM1).DesignAntitissue transglutaminase IgA (anti-TG IgA) was measured in the serum of 373 children affected with DM1 aged 1–19-year old and in 100 serum samples from non-diabetic control children. Histological examination was performed in 19 children seropositive for anti-TG IgA (17 DMI and 2 controls). Additionally, PCR-based analysis of Major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1) genotyping was implemented in three study population groups as follows: group 1 (n=25) (+ve DM1 and +ve CD), group 2 (n=63) (-ve DM1 and +ve CD) and control group 3 (n=2) (+ve CD).ResultsTwenty-six Sudanese children with DM1 out of 373 (6.97%) were seropositive for anti-TG IgA. Duodenal biopsy revealed Marsh 2 and 3 in 13 out of 17 (76.47%) seropositive anti-TG IgA patients with DM1. Significant association (pConclusionsAnti-TG IgA titre of greater than 10 times upper limit of normal (≥10× ULN) can be useful for detecting CD in children with type 1 diabetes without duodenal biopsy. HLA testing in children with DM1 appears to provide little added benefit given the high prevalence (96%) of HLA DQ2/DQ8 in children with DM1. |
| وصف الملف: | fulltext |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa77d4c4b0db6177e720e44c3ee2fa44 https://trepo.tuni.fi/handle/10024/139503 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fa77d4c4b0db6177e720e44c3ee2fa44 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |