A population-based epidemiology of Wilson’s disease in South Korea between 2010 and 2016
| العنوان: | A population-based epidemiology of Wilson’s disease in South Korea between 2010 and 2016 |
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| المؤلفون: | Yong Kang Lee, Chun Kyon Lee, Sun Young Won, Jeong Hun Seo, Min Jin Kang, Eun Ju Choe, Han Ho Jeon, Yong Suk Cho, Byung Kyu Park, Jongwon Choi, Jae Bock Chung |
| المصدر: | Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Pediatrics, medicine.medical_specialty, Cirrhosis, Adolescent, Databases, Factual, Population, lcsh:Medicine, Disease, History, 21st Century, Article, Young Adult, 03 medical and health sciences, Medical research, 0302 clinical medicine, Hepatolenticular Degeneration, Republic of Korea, Epidemiology, Prevalence, Humans, Medicine, Young adult, education, lcsh:Science, Aged, Aged, 80 and over, education.field_of_study, Multidisciplinary, Hepatology, business.industry, Incidence, Incidence (epidemiology), Mortality rate, lcsh:R, Gastroenterology, Middle Aged, medicine.disease, Wilson's disease, 030104 developmental biology, Population Surveillance, Female, lcsh:Q, business, 030217 neurology & neurosurgery |
| الوصف: | Very few population-based studies have examined the epidemiology of Wilson’s disease (WD). We investigated the epidemiology of WD using the National Health Insurance Service (NHIS) database in South Korea. We analyzed not only the statistical variables of WD, but also those of WD-related diseases. WD patients were identified with the relevant International Classification of Diseases-10 code out of 50.5 million people. We used the NHIS database from 2009 to 2016 and analyzed the incidence rate, prevalence, and clinical symptoms of WD. A total of 1,333 patients were identified. The average annual incidence rate was 3.8 per million person-years. The prevalence was 38.7 per million people. The mean diagnostic age was 26.1 ± 17.2 with earlier diagnosis in men (P = 0.0003). Among the patients, 988 (74.1%) had hepatic symptoms, 510 (38.3%) had neurologic symptoms, and 601 (45.1%) had psychiatric symptoms. Before the diagnosis of WD, 350 (26.3%) had neurologic symptoms, and 427 (32%) had psychiatric symptoms. The annual mortality rate was 0.7%. Age, liver cirrhosis, and liver failure correlated with a fatal prognosis (P |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7bc4c61d1d8657eb8477bdd002b5fa http://link.springer.com/article/10.1038/s41598-020-70976-1 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fb7bc4c61d1d8657eb8477bdd002b5fa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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