Tenecteplase in wake-up ischemic stroke trial : Protocol for a randomized-controlled trial
| العنوان: | Tenecteplase in wake-up ischemic stroke trial : Protocol for a randomized-controlled trial |
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| المؤلفون: | Mirza Jusufovic, Jukka Putaala, A. Tveiten, Bent Indredavik, Gian Marco De Marchis, Jesper Petersson, Janika Kõrv, Haakon Lindekleiv, Melinda B Roaldsen, Agnethe Eltoft, Stefan T. Engelter, David J. Werring, Ellisiv B. Mathiesen, Hanne Christensen, Mary Helen Søyland, Eivind Berge, Dalius Jatužis, Thompson G. Robinson, Tom Wilsgaard |
| المساهمون: | HUS Neurocenter, Neurologian yksikkö, University of Helsinki, Helsinki University Hospital Area |
| المصدر: | International journal of stroke, London : SAGE, 2021, vol. 16, no. 8, p. 990-994 International Journal of Stroke Roaldsen, M B, Lindekleiv, H, Eltoft, A, Jusufovic, M, Søyland, M H, Petersson, J, Indredavik, B, Tveiten, A, Putaala, J, Christensen, H, Kõrv, J, Jatužis, D, Engelter, S T, Marco De Marchis, G, Wilsgaard, T, Werring, D J, Robinson, T, Mathiesen, E B & Berge, E 2021, ' Tenecteplase in wake-up ischemic stroke trial : Protocol for a randomized-controlled trial ', International Journal of Stroke, vol. 16, no. 8, pp. 990-994 . https://doi.org/10.1177/1747493020984073 International journal of stroke, London : SAGE, 2021, first on line, p. [1-5] |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, acute ischemic stroke, Neurology, VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803, medicine.medical_treatment, Trial protocol, TWIST, Tenecteplase, intravenous thrombolysis, wake-up stroke, 030204 cardiovascular system & hematology, 3124 Neurology and psychiatry, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, Protocol, medicine, Acute ischemic stroke, business.industry, Wake up stroke, 3112 Neurosciences, Thrombolysis, 3. Good health, VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803, 3121 General medicine, internal medicine and other clinical medicine, Ischemic stroke, Cardiology, business, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | Background Patients with wake-up ischemic stroke who have evidence of salvageable tissue on advanced imaging can benefit from intravenous thrombolysis. It is not known whether patients who do not fulfil such imaging criteria might benefit from treatment, but studies indicate that treatment based on non-contrast CT criteria may be safe. Tenecteplase has shown promising results in patients with acute ischemic stroke. The aim of the Tenecteplase in Wake-up Ischemic Stroke Trial (TWIST) is to compare the effect of thrombolytic treatment with tenecteplase and standard care versus standard care alone in patients with wake-up ischemic stroke selected by non-contrast CT. Methods/design TWIST is an international, investigator-initiated, multi-centre, prospective, randomized-controlled, open-label, blinded end-point trial of tenecteplase ( n = 300) versus standard care ( n = 300) in patients who wake up with an acute ischemic stroke and can be treated within 4.5 h upon awakening. Seventy-seven centres in 10 countries (Denmark, Estonia, Finland, Latvia, Lithuania, New Zealand, Norway, Sweden, Switzerland, and the United Kingdom) participate. The primary outcome is the modified Rankin Scale on the ordinal scale (0–6) at three months. Discussion TWIST aims to determine the effect and safety of thrombolytic treatment with tenecteplase in patients with wake-up ischemic stroke selected by non-contrast CT. Trial registration ClinicalTrials.gov NCT03181360. EudraCT Number 2014-000096-80. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1747-4930 1747-4949 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc8a3ee39e7fed1d3663259e4088306e http://hdl.handle.net/10138/337310 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fc8a3ee39e7fed1d3663259e4088306e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17474930 17474949 |
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