Prevalence and Prognosis of Portopulmonary Hypertension in 223 Liver Transplant Recipients
| العنوان: | Prevalence and Prognosis of Portopulmonary Hypertension in 223 Liver Transplant Recipients |
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| المؤلفون: | Xuedong Shen, Jianjun Zhang, Zhiqing Qiao, Qi Zhuang, Ying Zheng, Jieyan Shen, Xueming Zhang, Jian Li |
| المصدر: | Canadian Respiratory Journal Canadian Respiratory Journal, Vol 2018 (2018) |
| بيانات النشر: | Hindawi Limited, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Liver Cirrhosis, Male, medicine.medical_treatment, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Liver transplantation, Gastroenterology, Liver disease, 0302 clinical medicine, Risk Factors, Cause of Death, Prevalence, Cause of death, Portopulmonary hypertension, Liver Neoplasms, Middle Aged, Prognosis, Survival Rate, surgical procedures, operative, Echocardiography, Portal hypertension, Female, 030211 gastroenterology & hepatology, Research Article, Adult, Pulmonary and Respiratory Medicine, China, medicine.medical_specialty, Carcinoma, Hepatocellular, Article Subject, Hypertension, Pulmonary, Diseases of the respiratory system, 03 medical and health sciences, Hepatitis B, Chronic, Internal medicine, Hypertension, Portal, medicine, Humans, Mortality, Survival rate, Survival analysis, Retrospective Studies, RC705-779, business.industry, Pneumonia, medicine.disease, Pulmonary hypertension, Liver Transplantation, Logistic Models, Multivariate Analysis, business, Liver Failure |
| الوصف: | Objective. To investigate the prevalence and prognosis of portopulmonary hypertension (PoPH) in liver transplant recipients. Methods. Patients with advanced liver disease who underwent orthotopic liver transplantation (OLT) were included in this retrospective study from January 2012 to June 2015. According to the 2015 European Society of Cardiology (ESC)/European Respiratory Society (ERS) guidelines for the diagnosis of pulmonary hypertension (PH), patients with tricuspid regurgitation velocity (TRV) >3.4 m/s or 2.9 m/s ≤ TRV ≤ 3.4 m/s coexisting with other echocardiographic PH signs were judged as PH. PH patients with portal hypertension and without other known causes of PH were diagnosed as PoPH. Results. A total of 223 (170 males and 53 females) middle-aged (50.9 ± 9 years old) liver transplant recipients were included in this study. Fourteen patients (6.3%) were diagnosed with PoPH, and none of the patients were treated with vasodilators before or after OLT. After OLT, patients were followed up for 26 ± 13.5 months. In total, 8 of 14 (57%) PoPH patients died, and the main cause of death was pulmonary infection. Kaplan–Meier survival curves revealed a significant difference in survival between PoPH and non-PoPH patients (p<0.001), and the median survival time after OLT of PoPH was 11.4 months. Conclusions. The prevalence of PoPH was 6.3% in OLT recipients. The survival of untreated PoPH patients was dismal after OLT. |
| وصف الملف: | text/xhtml |
| تدمد: | 1916-7245 1198-2241 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce10381250a550cd50fc6826a03d95b https://doi.org/10.1155/2018/9629570 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fce10381250a550cd50fc6826a03d95b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19167245 11982241 |
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