Otomycosis usually develops in hot humid climates, and patients with otomycosis generally show a good response to medical treatment. However, invasive otomycosis is rarely observed in immunocompetent patients. The predisposing factors for invasive otomycosis include malignant neoplasms and increased use of steroids and broad-spectrum antibiotics. We report a unique case of iatrogenic invasive otomycosis in a 35-year-old woman who had been given ofloxacin eardrops over a long period, which led to an invasive fungal infection. The patient showed no response to general antifungal agents, but the infection was successfully controlled with voriconazole.
