Biphasic effect of mechanical stress on lymphocyte activation
| العنوان: | Biphasic effect of mechanical stress on lymphocyte activation |
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| المؤلفون: | YASSOUF, MHD YOUSUF |
| المصدر: | Journal of Cellular Physiology. 237(2):1521-1531 |
| بيانات النشر: | Wiley Periodicals LLC, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | biphasic effect, mechanical stress, immune response, lymphocyte activation, mechanotransduction |
| الوصف: | Mechanical forces can modulate the immune response, mostly described as promoting the activation of immune cells, but the role and mechanism of pathological levels of mechanical stress in lymphocyte activation have not been focused on before. By an ex vivo experimental approach, we observed that mechanical stressing of murine spleen lymphocytes with 50 mmHg for 3 h induced the nuclear localization of NFAT1, increased C-Jun, and increased the expression of early activation marker CD69 in resting CD8+ cells. Interestingly, 50 mmHg mechanical stressing induced the nuclear localization of NFAT1; but conversely decreased C-Jun and inhibited the expression of CD69 in lymphocytes under lipopolysaccharide or phorbol 12-myristate 13-acetate/ionomycin stimulation. Additionally, we observed similar changes trends when comparing RNA-seq data of hypertensive and normotensive COVID-19 patients. Our results indicate a biphasic effect of mechanical stress on lymphocyte activation, which provides insight into the variety of immune responses in pathologies involving elevated mechanical stress. 長崎大学学位論文 学位記番号:博(医歯薬)甲第1527号 学位授与年月日:令和5年3月20日 Author: Mhd Yousuf Yassouf, Xu Zhang, Zisheng Huang, Da Zhai, Reiko Sekiya, Tsuyoshi Kawabata, Tao-Sheng Li Citation: Journal of Cellular Physiology, 237(2), pp. 1521-1531; 2022 |
| اللغة: | English |
| تدمد: | 0021-9541 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=jairo_______::c384acf2417b0bcc3584657ce70c887f http://hdl.handle.net/10069/00042368 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.jairo.........c384acf2417b0bcc3584657ce70c887f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00219541 |
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