التفاصيل البيبلوغرافية
| العنوان: |
Biodegradable Nanoprodrugs: 'Delivering' ROS to Cancer Cells for Molecular Dynamic Therapy |
| المؤلفون: |
Tang, ZM, Liu, YY, Ni, DL, Zhou, JJ, Zhang, M, Zhao, PR, Lv, B, Wang, H, Jin, DY, Bu, WB |
| بيانات النشر: |
Wiley, 2020. |
| سنة النشر: |
2020 |
| مصطلحات موضوعية: |
02 Physical Sciences, 03 Chemical Sciences, 09 Engineering, Nanoscience & Nanotechnology |
| الوصف: |
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Biodegradable nanoprodrugs, inheriting the antitumor effects of chemotherapy drugs and overcoming the inevitable drawback of side effects on normal tissues, hold promise as next-generation cancer therapy candidates. Biodegradable nanoprodrugs of transferrin-modified MgO2 nanosheets are developed to selectively deliver reactive oxygen species to cancer cells for molecular dynamic therapy strategy. The nanosheets favor the acidic and low catalase activity tumor microenvironment to react with proton and release nontoxic Mg2+. This reaction simultaneously produces abundant H2O2 to induce cell death and damage the structure of transferrin to release Fe3+, which will react with H2O2 to produce highly toxic ·OH to kill tumor cells. |
| وصف الملف: |
Print-Electronic; application/pdf |
| اللغة: |
English |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=od_______363::998971c438b7d8c2ebaac7c058195cd3
https://hdl.handle.net/10453/143507 |
| حقوق: |
CLOSED |
| رقم الأكسشن: |
edsair.od.......363..998971c438b7d8c2ebaac7c058195cd3 |
| قاعدة البيانات: |
OpenAIRE |
