Long-term consumption of isoflavone-enriched foods does not affect bone mineral density, bone metabolism, or hormonal status in early postmenopausal women : A randomized, double-blind, placebo controlled study
العنوان: | Long-term consumption of isoflavone-enriched foods does not affect bone mineral density, bone metabolism, or hormonal status in early postmenopausal women : A randomized, double-blind, placebo controlled study |
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المؤلفون: | Brink, Elizabeth, Coxam, Veronique, Robins, Simon, Wähälä, Kristiina, Cassidy, Aedin, Branca, Francesco, Kardinaal, Alwine, Klöpping-Ketelaars, Ineke, Kok, Linda, Fick, Henriette, Bosch, Linda van Den, Doest, Diane Ter, Westenbrink, Susanne, Brants, Henny, Aken, Petra Van, Rubingh, Carina, Kistemaker, Cor, Vendrig, Lizeth, Meijers, Truus, Brouns, Fred, d'Acapito, Paola, Mistura, Lorenza, Mattei, Valentina Di, Corsi, Annalisa, Ferrari, Marika, d'Errigo, Paola, Valtueña, Silvia, Toscano, Vincenzo, Cianfarani, Stefano, Giovagnoli, Mariarosa, Sette, Stefania, Cashman, Kevin, Chanteranne, Brigitte, Davicco, Marie-Jeanne, Lebecque, Patrice, Advenier, Martine, Brandolini, Marion, Duboeuf, François, Samaletdin, Adile, Doat, Stephane, Braesco, Veronique, Joqueviel, Noelie, Ladroitte, Philippe, Talbot, Duncan |
المساهمون: | Netherlands Organisation for Applied Scientific Research, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Rowett Research Institute, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of East Anglia [Norwich] (UEA), Human Nutrition Unit, National Institute for Research on Food and Nutrition, Quality of Life (TNO), Department of Microbiology, Cerestar Research and Development Centre, Partenaires INRAE, Maastricht University [Maastricht], Centre de Recherche en Nutrition Humaine, Laboratoire de Nutrition Humaine, Centre de Recherche en Nutrition Humaine |
المصدر: | The American Journal of Clinical Nutrition The American Journal of Clinical Nutrition, Oxford University Press, 2008, 87 (3), pp.761-770 |
بيانات النشر: | HAL CCSD, 2008. |
سنة النشر: | 2008 |
مصطلحات موضوعية: | MENOPAUSE, HORMONE, DENSITE MINERALE OSSEUSE, ISOFLAVONE, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, BONE MINERAL DENSITY |
الوصف: | This trial was registered at clinicaltrials.gov as NCT00301353 and supported by the European Commission : Phytos QLRT-2000-00431 The PHYTOS investigators were : Alwine Kardinaal, Ineke Klöpping-Ketelaars, Linda Kok, Henriette Fick, Linda van den Bosch, Diane ter Doest, Susanne Westenbrink, Henry Brants, Petra van Aken, Carina Rubingh, Cor Kistemaker, Lizeth Vendrig, Truus Meijers, Fred Brouns, Paola D’Acapito, Lorenza Mistura, Valentina Di Mattei, Annalisa Corsi, Marika Ferrari, Paola D’Errigo, Silvia Valtueña, Vincenzo Toscano, Stefano Cianfarani, Mariarosa Giovagnoli, Stefania Sette, Kevin Cashman, Brigitte Chanteranne, Marie-Jeanne Davicco, Patrice Lebecque, Martine Advenier, Marion Brandolini, François Duboeuf, Adile Samaletdin, Stephane Doat, Veronique Braesco, Noelie Joqueviel, Philippe Ladroitte, and Duncan Talbot; International audience; BACKGROUND: Osteoporosis is a major health problem. It was hypothesized that isoflavone-containing products may be a potential alternative to hormone replacement therapy for preventing bone loss during the menopausal transition. OBJECTIVE: The objective was to investigate whether the consumption of isoflavone-enriched foods for 1 y affects bone mineral density, bone metabolism, and hormonal status in early postmenopausal women. DESIGN: This was a randomized, double-blind, placebo-controlled, parallel, multicenter trial. Two hundred thirty-seven healthy early postmenopausal women [mean (+/-SD) age of 53 +/- 3 y and time since last menses of 33 +/- 15 mo] consumed isoflavone-enriched foods providing a mean daily intake of 110 mg isoflavone aglycones or control products for 1 y while continuing their habitual diet and lifestyle. Outcome measures included bone mineral density of the lumbar spine and total body, markers of bone formation and bone resorption, hormones, isoflavones in plasma and urine, safety variables, and adverse events. RESULTS: Consumption of isoflavone-enriched products did not alter bone mineral density of the lumbar spine and total body or markers of bone formation and bone resorption. Hormone concentrations did not differ between the isoflavone and control groups. Consumption of isoflavone-enriched products resulted in increased isoflavone concentrations in plasma and urine, whereas control products did not. This finding indicated good compliance with treatment. Subgroup analysis did not support an effect of equol phenotype on bone density. The intervention had no effect on a range of safety variables and reported adverse events. CONCLUSION: Consumption of foods containing 110 mg/d of soy isoflavone aglycone equivalents for 1 y did not prevent postmenopausal bone loss and did not affect bone turnover in apparently healthy early postmenopausal white women. |
اللغة: | English |
تدمد: | 0030-1353 0002-9165 1938-3207 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=od______2885::fa0b629bfe64175a4c7e5369ce6a8514 https://hal.inrae.fr/hal-02662080 |
رقم الأكسشن: | edsair.od......2885..fa0b629bfe64175a4c7e5369ce6a8514 |
قاعدة البيانات: | OpenAIRE |
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