Clinical applications of pharmacogenomics
| العنوان: | Clinical applications of pharmacogenomics |
|---|---|
| المؤلفون: | Quiñones,Luis, Roco,Ángela, Cayún,Juan P, Escalante,Paula, Miranda,Carla, Varela,Nelson, Meneses,Francisca, Gallegos,Bastián, Zaruma-Torres,Fausto, Lares-Asseff,Ismael |
| المصدر: | Revista médica de Chile v.145 n.4 2017 SciELO Chile CONICYT Chile instacron:CONICYT |
| بيانات النشر: | Sociedad Médica de Santiago, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Genetic, Pharmacogenetics, Pharmacokinetics, Pharmacogenomic variants, Polymorphisms |
| الوصف: | Pharmacogenomics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, distribution, biotransformation and excretion as well as the drug-target interaction. Therefore, the presence of allelic variants will classify people as poor, extensive or rapid/ultra rapid metabolizers, modifying drug efficacy and safety. In this work, the state of art in relation to this discipline is presented and the genetic variants of enzymes that are involved in drug pharmacokinetics or pharmacodynamics are described. The effects of these variants on the therapeutic response to drugs used in our country are also discussed. |
| وصف الملف: | text/html |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=od______3056::ec4af75f96f4601b75212704ffa16b62 http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000400009 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.od......3056..ec4af75f96f4601b75212704ffa16b62 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |