(11)C-choline PET/CT and multiparametric MRI in patients with biochemical relapse of prostate cancer
العنوان: | (11)C-choline PET/CT and multiparametric MRI in patients with biochemical relapse of prostate cancer |
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المؤلفون: | J R, Garcia, N, Romera, M, Cozar, M, Soler, M, Moragas, M, Escobar |
المصدر: | Actas urologicas espanolas. 39(4) |
سنة النشر: | 2014 |
مصطلحات موضوعية: | Male, Prostatectomy, Prostatic Neoplasms, Bone Neoplasms, Adenocarcinoma, Prostate-Specific Antigen, Combined Modality Therapy, Magnetic Resonance Imaging, Choline, Recurrence, Lymphatic Metastasis, Positron Emission Tomography Computed Tomography, Humans, Carbon Radioisotopes, Neoplasm Recurrence, Local, Radiopharmaceuticals, Retrospective Studies |
الوصف: | To assess the diagnostic usefulness of (11)C-choline PET/CT vs. multi-parametric MRI in the prostate cancer relapse. A retrospective study of 21 patients with prostate cancer treated initially with surgery (n=12), radiotherapy (n=9). PSA levels were increased (post-surgery: .3-3.6 ng/ml; post-radiotherapy: 2.4-8.8 ng/ml). In an interval of time of 15 days all patients were underwent to: whole-body-dual-modality PET-CT carried out early after (11)C-choline (296 ± 29 MBq) injection, and multiparametric prostate MRI with paramagnetic intravenous contrast (using anatomical imaging sequences, diffusion-weighted imaging and dynamic contrast-enhanced imaging). On the basis of our results, all patients were underwent to directed diagnosis and/or clinical, analytic and imaging follow-up. In 15 patients (71.4%) both procedures showed concordant results: 4 negative and 11 positive cases [7 local recurrences, 3 isolated pelvic lymph nodes (2 infracentimetric), 1 local relapse and only one M1 bone metastases]. The results were discordant in 6 patients (28.6%): 3 local relapses in MRI with no PET significance, 1 local relapse in PET with no MRI significance. 2 bone metastases were identified with PET (out of the field-of-view of MRI).(11)C-choline PET/CT and multi-parametric MRI play a complementary role in the detection of local relapse in prostate cancer patients, with similar sensitivity for the detection of lymph involvement. Whole-body 11C-choline PET/CT technique is also useful for bone staging. |
تدمد: | 1699-7980 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid________::5896aa3190e7b6af58034a81b896e280 https://pubmed.ncbi.nlm.nih.gov/25454265 |
رقم الأكسشن: | edsair.pmid..........5896aa3190e7b6af58034a81b896e280 |
قاعدة البيانات: | OpenAIRE |
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