Whole Genome Sequence of
العنوان: | Whole Genome Sequence of |
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المؤلفون: | Wael M, Abdel-Mageed, Bertalan, Juhasz, Burhan, Lehri, Ali S, Alqahtani, Imen, Nouioui, Dawrin, Pech-Puch, Jioji N, Tabudravu, Michael, Goodfellow, Jaime, Rodríguez, Marcel, Jaspars, Andrey V, Karlyshev |
المصدر: | Marine Drugs |
سنة النشر: | 2019 |
مصطلحات موضوعية: | Geologic Sediments, Whole Genome Sequencing, Acclimatization, Oceans and Seas, Article, biosynthetic gene clusters, Actinobacteria, genome sequencing, Dermacoccus abyssi MT1.1T, dermacozines, Mariana Trench, RNA, Ribosomal, 16S, Animals, Phenazines, Phylogeny |
الوصف: | Dermacoccus abyssi strain MT1.1T is a piezotolerant actinobacterium that was isolated from Mariana Trench sediment collected at a depth of 10898 m. The organism was found to produce ten dermacozines (A‒J) that belonged to a new phenazine family and which displayed various biological activities such as radical scavenging and cytotoxicity. Here, we report on the isolation and identification of a new dermacozine compound, dermacozine M, the chemical structure of which was determined using 1D and 2D-NMR, and high resolution MS. A whole genome sequence of the strain contained six secondary metabolite-biosynthetic gene clusters (BGCs), including one responsible for the biosynthesis of a family of phenazine compounds. A pathway leading to the biosynthesis of dermacozines is proposed. Bioinformatic analyses of key stress-related genes provide an insight into how the organism adapted to the environmental conditions that prevail in the deep-sea. |
تدمد: | 1660-3397 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid________::93200eb4d23a9083586c635154aa893f https://pubmed.ncbi.nlm.nih.gov/32106586 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.pmid..........93200eb4d23a9083586c635154aa893f |
قاعدة البيانات: | OpenAIRE |
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