The angiotensin converting enzyme I/D polymorphism in long distance runners
العنوان: | The angiotensin converting enzyme I/D polymorphism in long distance runners |
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المؤلفون: | H, Hruskovicová, D, Dzurenková, M, Selingerová, B, Bohus, B, Timkanicová, L, Kovács |
المصدر: | The Journal of sports medicine and physical fitness. 46(3) |
سنة النشر: | 2006 |
مصطلحات موضوعية: | Adult, Aspartic Acid, Slovakia, Polymorphism, Genetic, Adolescent, Genotype, Middle Aged, Peptidyl-Dipeptidase A, Running, Age Distribution, Gene Frequency, Predictive Value of Tests, Skating, Linear Models, Physical Endurance, Humans, Controlled Clinical Trials as Topic, Isoleucine, Child, Aged |
الوصف: | There is an assumption that ACE I/D polymorphism represents one of the possible genetic factors that might be associated with sports excellence. Recent studies have identified an increased frequency of I allele in elite endurance athletes, long distance runners, rowers and mountaineers. The aim of this study was to test the hypothesis that the ACE I/D polymorphism is associated with enhanced endurance performance.We examined this hypothesis by determining ACE I/D allele frequency in 215 marathon runners, 222 half-marathon runners and 18 inline skaters classified by performance (marathon competition results). ACE genotype and allele frequencies were compared with 252 healthy controls.ACE genotype frequency in the whole cohort did not differ from that in the sedentary controls (P0.56). However, there was an increase of the I/I genotype incidence amongst successful marathon runners scoring on places from 1st to 150th (P0.01). These findings were confirmed in the group of inline skaters, similarly demonstrating an increase of the I/I genotype (P0.01). There was no association found between half marathon runners and the ACE genotype (P0.59).An excess of the I allele in long distance runners confirms the association between the ACE I/D polymorphism and endurance sports performance. |
تدمد: | 0022-4707 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid________::b037a96423653411ccddaffd0f497f5e https://pubmed.ncbi.nlm.nih.gov/16998460 |
رقم الأكسشن: | edsair.pmid..........b037a96423653411ccddaffd0f497f5e |
قاعدة البيانات: | OpenAIRE |
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