Synthesis and Biological Activity of Novel Zinc-Itraconazole Complexes in Protozoan Parasites and
| العنوان: | Synthesis and Biological Activity of Novel Zinc-Itraconazole Complexes in Protozoan Parasites and |
|---|---|
| المؤلفون: | Jose Aleixo de, Azevedo-França, Renato, Granado, Sara Teixeira, de Macedo Silva, Gabrielle Dos, Santos-Silva, Sandra, Scapin, Luana P, Borba-Santos, Sonia, Rozental, Wanderley, de Souza, Érica S, Martins-Duarte, Emile, Barrias, Juliany Cola Fernandes, Rodrigues, Maribel, Navarro |
| المصدر: | Antimicrob Agents Chemother |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Leishmania, Zinc, Antifungal Agents, Antiparasitic Agents, Parasitic Sensitivity Tests, Susceptibility, Sporothrix, Trypanosoma cruzi, parasitic diseases, Leishmania mexicana, Microbial Sensitivity Tests, Itraconazole, Toxoplasma |
| الوصف: | The new complexes Zn(ITZ)(2)Cl(2) (1) and Zn(ITZ)(2)(OH)(2) (2) were synthetized by a reaction of itraconazole with their respective zinc salts under reflux. These Zn-ITZ complexes were characterized by elemental analyses, molar conductivity, mass spectrometry, (1)H and (13)C{(1)H} nuclear magnetic resonance, and UV-vis and infrared spectroscopies. The antiparasitic and antifungal activity of Zn-ITZ complexes was evaluated against three protozoans of medical importance, namely, Leishmania amazonensis, Trypanosoma cruzi, and Toxoplasma gondii, and two fungi, namely, Sporothrix brasiliensis and Sporothrix schenckii. The Zn-ITZ complexes exhibited a broad spectrum of action, with antiparasitic and antifungal activity in low concentrations. The strategy of combining zinc with ITZ was efficient to enhance ITZ activity since Zn-ITZ-complexes were more active than the azole alone. This study opens perspectives for future applications of these Zn-ITZ complexes in the treatment of parasitic diseases and sporotrichosis. |
| تدمد: | 1098-6596 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid________::ba61e195b0a9353c290b967260d2b747 https://pubmed.ncbi.nlm.nih.gov/32152072 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.pmid..........ba61e195b0a9353c290b967260d2b747 |
| قاعدة البيانات: | OpenAIRE |
كن أول من يترك تعليقا!