Hepatocellular carcinoma (HCC) owns the high morbidity and mortality rates. Surgical resection is still the major pathway for the longer survival of HCC patients. Postoperative recurrence and metastasis have become the key impairment of prognosis of HCC patients. The relationship between tumor recurrence and surgical manner underwent by HCC patients is complicated and multiple factors are included. When the liver tumor was pressured during operation, tumor cells could be squeezed into blood flow via the broken vessels, which resulted in tumor metastasis. Besides, ischemia-reperfusion injury induced by Pringle maneuver during the liver blood blockade resulted in the immune destruction of liver and induced tumor recurrence.The destruction of physical barriers consisted of interstitial cells and normal liver cells was also a key factor for tumor recurrence. This paper summarizes the possible relationship between postoperative recurrence and surgical manner in HCC patients to provide the preventive suggestions for the postoperative recurrence of HCC patients.肝癌的发病率高、死亡率高，外科手术依然是实现肝癌患者长期生存的最主要途径，而术后的复发转移已成为影响患者预后的关键。肝癌手术方式与术后复发的关系复杂，涉及到多种因素。外科手术操作中肝肿瘤受压后，可导致肿瘤细胞沿着破损的血管进入血液循环而发生转移；全肝血流阻断中使用Pringle手法导致的缺血再灌注损伤可降低肝脏的免疫防护功能，引起肿瘤复发；断肝过程中作为物理屏障的正常肝细胞和间质细胞的破坏，会引起肝癌患者术后的复发。文章将肝癌手术方式与术后复发的关系进行初步阐述与总结，以期为肝癌患者术后复发的预防提供思路。.
