Structural retinal changes in cerebral small vessel disease
| العنوان: | Structural retinal changes in cerebral small vessel disease |
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| المؤلفون: | Langner, S Magdalena, Terheyden, Jan H, Geerling, Clara F, Kindler, Christine, Keil, Vera C W, Turski, Christopher A, Turski, Gabrielle N, Behning, Charlotte, Wintergerst, Maximilian W M, Petzold, Gabor C, Finger, Robert P |
| المساهمون: | Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging |
| المصدر: | Scientific reports 12, 9315 (2022). doi:10.1038/s41598-022-13312-z Scientific Reports, 12(1):9315. Nature Publishing Group Langner, S M, Terheyden, J H, Geerling, C F, Kindler, C, Keil, V C W, Turski, C A, Turski, G N, Behning, C, Wintergerst, M W M, Petzold, G C & Finger, R P 2022, ' Structural retinal changes in cerebral small vessel disease ', Scientific Reports, vol. 12, no. 1, 9315, pp. 9315 . https://doi.org/10.1038/s41598-022-13312-z |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Retinal Ganglion Cells, methods [Tomography, Optical Coherence], genetic structures, pathology [Nerve Fibers], pathology [Retinal Ganglion Cells], eye diseases, Retina, pathology [Retina], diagnostic imaging [Retina], Nerve Fibers, Case-Control Studies, Cerebral Small Vessel Diseases, pathology [Cerebral Small Vessel Diseases], Humans, sense organs, diagnostic imaging [Cerebral Small Vessel Diseases], ddc:600, Tomography, Optical Coherence |
| الوصف: | Cerebral small vessel disease (CSVD) is an important contributor to cognitive impairment and stroke. Previous research has suggested associations with alterations in single retinal layers. We have assessed changes of all individual retinal layers in CSVD using high-resolution optical coherence tomography (OCT) for the first time. Subjects with recent magnetic resonance imaging (MRI) underwent macular and peripapillary retinal imaging using OCT for this case-control study. Number and volume ratio index (WMRI) of white matter lesions (WML) were determined on MRI. Data were analyzed using multiple linear regression models. 27 CSVD patients and 9 control participants were included. Ganglion cell layer (GCL) volume was significantly reduced in patients with CSVD compared to age-matched controls (p = 0.008). In patients with CSVD, larger foveal outer plexiform layer (OPL) volume and decreased temporal peripapillary retinal nerve fiber layer (RNFL) thickness were significantly associated with a higher WMRI in linear regression when controlling for age (p ≤ 0.033). Decreased foveal GCL volume and temporal-inferior RNFL thickness at Bruch's membrane opening (MRW), and increased temporal MRW were associated with a higher WML burden (p ≤ 0.037). Thus, we identified alterations in several OCT layers in individuals with CSVD (GCL, OPL, MRW and RNFL). Their potential diagnostic value merits further study. |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::22b237abf38a89049fd6c53c3496bff1 https://pubmed.ncbi.nlm.nih.gov/35662264 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.pmid.dedup....22b237abf38a89049fd6c53c3496bff1 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 20452322 |
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