Immune-mediated necrotizing myopathy due to statins exposure
| العنوان: | Immune-mediated necrotizing myopathy due to statins exposure |
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| المؤلفون: | Villa, L., Lerario, A., Calloni, S., Peverelli, L., Matinato, C., Liso, F., Ceriotti, F., Tironi, R., Monica Sciacco, Moggio, M., Triulzi, F., Cinnante, C. |
| المصدر: | Acta Myologica Scopus-Elsevier |
| بيانات النشر: | Pacini Editore srl, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, Biopsy, necrotizing myopathy, Middle Aged, Magnetic Resonance Imaging, Autoimmune Diseases, Necrosis, Muscular Diseases, HMGCR autoantibodies, Humans, Female, Hydroxymethylglutaryl CoA Reductases, Original Article, muscular MRI, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Correlation of Data, Muscle, Skeletal, Autoantibodies, Retrospective Studies |
| الوصف: | Statin-induced necrotizing autoimmune myopathy (IMNM) is an autoimmune disorder induced by anti-3-hydroxy-3-methylglutaryl-coenzyme-A reductase (anti-HMGCR) antibodies. We performed a retrospective clinical, histological, and radiological evaluation of 5 patients with a 3-year therapeutic follow-up. All patients used statins and then experienced proximal weakness that persisted after drug cessation. Muscle biopsies revealed a primary necrotizing myopathy without inflammatory infiltrates. All patients required immunomodulant combination therapy to achieve clinical remission. Magnetic resonance imaging (MRI) showed the presence of edema in the medial gastrocnemius, posterior and central loggia of the thigh, posterior loggia of the arm, and the infraspinatus and subscapularis muscles, as well as extensive inflammation of the subcutaneous tissues and muscolaris fasciae. Serum analysis, muscle biopsy, and MRI are fundamental for IMNM diagnosis and follow-up. The growing use of statins in the general population raises the importance of acquaintance with this disease in clinical practice. |
| اللغة: | English |
| تدمد: | 2532-1900 1128-2460 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::49d3a7973e6947eeba29f7ca3ce7bce1 http://europepmc.org/articles/PMC6416701 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.pmid.dedup....49d3a7973e6947eeba29f7ca3ce7bce1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25321900 11282460 |
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