تقرير
Population stability risks and biophysical benefits of cell-cell fusion in macrophage, osteoclast, and giant multinucleated cells
| العنوان: | Population stability risks and biophysical benefits of cell-cell fusion in macrophage, osteoclast, and giant multinucleated cells |
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| المؤلفون: | Silverberg, Jesse L., Ng, Pei Ying, Baron, Roland, Yin, Peng |
| سنة النشر: | 2019 |
| المجموعة: | Condensed Matter Physics (Other) |
| مصطلحات موضوعية: | Physics - Biological Physics, Condensed Matter - Soft Condensed Matter |
| الوصف: | Plant and animal cells are commonly understood as acquiring specialized functions through differentiation and asymmetric division. However, unique capabilities are also acquired when two or more cells fuse together, mixing cytoplasmic and genetic material. Here, we combine imaging experiments with biophysical modeling to perform the first risk-benefit analysis of cell-cell fusion. On one hand, we find fusion introduces an intrinsic instability to the population dynamics. On the other hand, we measure an unusual physiological scaling suggesting these cells grow substantially larger at lower energetic costs. Further analysis of the cytoskeleton finds a size-associated phase separation of F-actin that self-organizes multinucleated cell phenotypes. Comment: 4 main text figures + 7 supplemental figures |
| نوع الوثيقة: | Working Paper |
| URL الوصول: | http://arxiv.org/abs/1906.00441 |
| رقم الأكسشن: | edsarx.1906.00441 |
| قاعدة البيانات: | arXiv |
| الوصف غير متاح. |