تقرير
A structural model for the Coronavirus Nucleocapsid
| العنوان: | A structural model for the Coronavirus Nucleocapsid |
|---|---|
| المؤلفون: | Coscio, Federico, Nadra, Alejandro D., Ferreiro, Diego U. |
| سنة النشر: | 2020 |
| المجموعة: | Quantitative Biology |
| مصطلحات موضوعية: | Quantitative Biology - Biomolecules |
| الوصف: | We propose a mesoscale model structure for the coronavirus nucleocapsid, assembled from the high resolution structures of the basic building blocks of the N-protein, CryoEM imaging and mathematical constraints for an overall quasi-spherical particle. The structure is a truncated octahedron that accommodates two layers: an outer shell composed of triangular and quadrangular lattices of the N-terminal domain and an inner shell of equivalent lattices of coiled parallel helices of the C-terminal domain. The model is consistent with the dimensions expected for packaging large viral genomes and provides a rationale to interpret the apparent pleomorphic nature of coronaviruses. Comment: 13 pages, 5 figures |
| نوع الوثيقة: | Working Paper |
| URL الوصول: | http://arxiv.org/abs/2005.12165 |
| رقم الأكسشن: | edsarx.2005.12165 |
| قاعدة البيانات: | arXiv |
| الوصف غير متاح. |