Using the first cohomology from the mirror Heisenberg-Virasoro algebra to the twisted Heisenberg algebra (as the mirror Heisenberg-Virasoro algebra-module), in this paper we determined the derivations on the mirror Heisenberg-Virasoro algebra. Based on this result, we proved that any 2-local derivation on the mirror Heisenberg-Virasoro algebra is a derivation.
