تقرير
The role of APOBEC3-induced mutations in the differential evolution of monkeypox virus
| العنوان: | The role of APOBEC3-induced mutations in the differential evolution of monkeypox virus |
|---|---|
| المؤلفون: | Li, Xiangting, Habibipour, Sara, Chou, Tom, Yang, Otto O. |
| سنة النشر: | 2023 |
| المجموعة: | Condensed Matter Quantitative Biology |
| مصطلحات موضوعية: | Quantitative Biology - Populations and Evolution, Condensed Matter - Statistical Mechanics, Quantitative Biology - Genomics, Quantitative Biology - Quantitative Methods |
| الوصف: | Recent studies show that newly sampled monkeypox virus (MPXV) genomes exhibit mutations consistent with Apolipoprotein B mRNA Editing Catalytic Polypeptide-like3 (APOBEC3)-mediated editing, compared to MPXV genomes collected earlier. It is unclear whether these single nucleotide polymorphisms (SNPs) result from APOBEC3-induced editing or are a consequence of genetic drift within one or more MPXV animal reservoirs. We develop a simple method based on a generalization of the General-Time-Reversible (GTR) model to show that the observed SNPs are likely the result of APOBEC3-induced editing. The statistical features allow us to extract lineage information and estimate evolutionary events. Comment: 22 pages, 7 figures, Supplement |
| نوع الوثيقة: | Working Paper |
| URL الوصول: | http://arxiv.org/abs/2308.03714 |
| رقم الأكسشن: | edsarx.2308.03714 |
| قاعدة البيانات: | arXiv |
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