تقرير
Binding and dimerization control phase separation in a compartment
| العنوان: | Binding and dimerization control phase separation in a compartment |
|---|---|
| المؤلفون: | Rossetto, Riccardo, Wellecke, Gerrit, Zwicker, David |
| سنة النشر: | 2024 |
| المجموعة: | Condensed Matter Physics (Other) |
| مصطلحات موضوعية: | Physics - Biological Physics, Condensed Matter - Soft Condensed Matter, Condensed Matter - Statistical Mechanics |
| الوصف: | Biological cells exhibit a hierarchical spatial organization, where various compartments harbor condensates that form by phase separation. Cells can control the emergence of these condensates by affecting compartment size, the amount of the involved molecules, and their physical interactions. While physical interactions directly affect compartment binding and phase separation, they can also cause oligomerization, which has been suggested as a control mechanism. Analyzing an equilibrium model, we illustrate that oligomerization amplifies compartment binding and phase separation, which reinforce each other. This nonlinear interplay can also induce multistability, which provides additional potential for control. Our work forms the basis for deriving thermodynamically consistent kinetic models to understand how biological cells can regulate phase separation in their compartments. Comment: 6 pages, 5 figures |
| نوع الوثيقة: | Working Paper |
| URL الوصول: | http://arxiv.org/abs/2407.15179 |
| رقم الأكسشن: | edsarx.2407.15179 |
| قاعدة البيانات: | arXiv |
| الوصف غير متاح. |