تقرير
3D{\pi}: Three-Dimensional Positron Imaging, A Novel Total-Body PET Scanner Using Xenon-Doped Liquid Argon Scintillator
| العنوان: | 3D{\pi}: Three-Dimensional Positron Imaging, A Novel Total-Body PET Scanner Using Xenon-Doped Liquid Argon Scintillator |
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| المؤلفون: | Zabihi, Azam, Li, Xinran, Ramirez, Alejandro, Rolo, Manuel D. Da Rocha, Franco, Davide, Gabriele, Federico, Galbiati, Cristiano, Lai, Michela, Marlow, Daniel R., Renshaw, Andrew, Westerdale, Shawn, Wada, Masayuki |
| سنة النشر: | 2024 |
| المجموعة: | Physics (Other) |
| مصطلحات موضوعية: | Physics - Medical Physics |
| الوصف: | Objective: This paper introduces a novel PET imaging methodology called 3-dimensional positron imaging (3D{\pi}), which integrates total-body (TB) coverage, time-of-flight (TOF) technology, ultra-low dose imaging capabilities, and ultra-fast readout electronics inspired by emerging technology from the DarkSide collaboration. Approach: The study evaluates the performance of 3D{\pi} using Monte Carlo simulations based on NEMA NU 2-2018 protocols. The methodology employs a homogenous, monolithic scintillator composed of liquid argon (LAr) doped with xenon (Xe) with silicon photomultipliers (SiPM) operating at cryogenic temperatures. Main results: Significant enhancements in system performance are observed, with the 3D{\pi} system achieving a noise equivalent count rate (NECR) of 3.2 Mcps which is approximately two times higher than uEXPLORER's peak NECR (1.5 Mcps) at 17.3 (kBq/mL). Spatial resolution measurements show an average FWHM of 2.7 mm across both axial positions. The system exhibits superior sensitivity, with values reaching 373 kcps/MBq with a line source at the center of the field of view. Additionally, 3D{\pi} achieves a TOF resolution of 151 ps at 5.3 kBq/mL, highlighting its potential to produce high-quality images with reduced noise levels. Significance: The study underscores the potential of 3D{\pi} in improving PET imaging performance, offering the potential for shorter scan times and reduced radiation exposure for patients. The Xe-doped LAr offers advantages such as fast scintillation, enhanced light yield, and cost-effectiveness. Future research will focus on optimizing system geometry and further refining reconstruction algorithms to exploit the strengths of 3D{\pi} for clinical applications. Comment: 8 pages, 8 figures, 6 tables |
| نوع الوثيقة: | Working Paper |
| URL الوصول: | http://arxiv.org/abs/2408.14645 |
| رقم الأكسشن: | edsarx.2408.14645 |
| قاعدة البيانات: | arXiv |
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