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Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19

التفاصيل البيبلوغرافية
العنوان: Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19
المؤلفون: Allison K. Maher, Katie L. Burnham, Emma M. Jones, Michelle M. H. Tan, Rocel C. Saputil, Laury Baillon, Claudia Selck, Nicolas Giang, Rafael Argüello, Clio Pillay, Emma Thorley, Charlotte-Eve Short, Rachael Quinlan, Wendy S. Barclay, Nichola Cooper, Graham P. Taylor, Emma E. Davenport, Margarita Dominguez-Villar
المصدر: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
بيانات النشر: Nature Portfolio, 2022.
سنة النشر: 2022
المجموعة: LCC:Science
مصطلحات موضوعية: Science
الوصف: Although myeloid cell dysfunction has been observed in COVID-19, the underlying mechanisms remain incompletely understood. Here, the authors demonstrate that monocytes from patients with mild to moderate COVID-19 show a blunted innate immune response and a pro-thrombotic signature following secondary SARS-CoV-2 challenge.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-022-35638-y
URL الوصول: https://doaj.org/article/de001711bc5c459694d246aeb3195fa0
رقم الأكسشن: edsdoj.001711bc5c459694d246aeb3195fa0
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20411723
DOI:10.1038/s41467-022-35638-y