دورية أكاديمية
أعرض في EDS

Platelet-T cell aggregates in lung cancer patients: Implications for thrombosis.

التفاصيل البيبلوغرافية
العنوان: Platelet-T cell aggregates in lung cancer patients: Implications for thrombosis.
المؤلفون: Claire K Meikle, Adam J Meisler, Cara M Bird, Joseph A Jeffries, Nabila Azeem, Priyanka Garg, Erin L Crawford, Clare A Kelly, Tess Z Gao, Leah M Wuescher, James C Willey, Randall G Worth
المصدر: PLoS ONE, Vol 15, Iss 8, p e0236966 (2020)
بيانات النشر: Public Library of Science (PLoS), 2020.
سنة النشر: 2020
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Platelet-leukocyte aggregates (PLAs) are associated with increased thrombosis risk. The influence of PLA formation is especially important for cancer patients, since thrombosis accounts for approximately 10% of cancer-associated deaths. Our objective was to characterize and quantify PLAs in whole blood samples from lung cancer patients compared to healthy volunteers with the intent to analyze PLA formation in the context of lung cancer-associated thrombosis. Consenting lung cancer patients (57) and healthy volunteers (56) were enrolled at the Dana Cancer Center at the University of Toledo Health Science Campus. Peripheral blood samples were analyzed by flow cytometry. Patient medical history was reviewed through electronic medical records. Most importantly, we found lung cancer patients to have higher percentages of platelet-T cell aggregates (PTCAs) than healthy volunteers among both CD4+ T lymphocyte and CD8+ T lymphocyte populations. Our findings demonstrate that characterization of PTCAs may have clinical utility in differentiating lung cancer patients from healthy volunteers and stratifying lung cancer patients by history of thrombosis.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0236966
URL الوصول: https://doaj.org/article/e011d9450b4e492da9c8aa5b71f6cb13
رقم الأكسشن: edsdoj.011d9450b4e492da9c8aa5b71f6cb13
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0236966