دورية أكاديمية
أعرض في EDS

Earlier continuous renal replacement therapy is associated with reduced mortality in rhabdomyolysis patients

التفاصيل البيبلوغرافية
العنوان: Earlier continuous renal replacement therapy is associated with reduced mortality in rhabdomyolysis patients
المؤلفون: Xiayin Li, Ming Bai, Yan Yu, Feng Ma, Lijuan Zhao, Yajuan Li, Hao Wu, Lei Zhou, Shiren Sun
المصدر: Renal Failure, Vol 44, Iss 1, Pp 1743-1753 (2022)
بيانات النشر: Taylor & Francis Group, 2022.
سنة النشر: 2022
المجموعة: LCC:Diseases of the genitourinary system. Urology
مصطلحات موضوعية: Rhabdomyolysis, acute kidney injury, continue renal replacement therapy, mortality, creatine kinase, Diseases of the genitourinary system. Urology, RC870-923
الوصف: Background Continuous renal replacement therapy (CRRT) is commonly employed for rhabdomyolysis (RM) patients. However, the optimal initiation timing of CRRT and prognostic factors were not well evaluated for patients with RM. We aimed to investigate the efficacy of CRRT timing on mortality and the risk factors for death in RM patients who received CRRT.Methods RM patients who received CRRT between 1 May 2010 and 31 May 2021 in our center were retrospectively included. Univariate and multivariate logistic analyses were performed to identify the risk factors for primary outcome (90-day mortality).Results A total of 134 patients were included in our study. The 90-day mortality rate was 38.06%. The median time from CRRT initiation to peak CK occurrence was 4.8 h (IQR −16, 14), 67 patients received CRRT before 4.8 h after peak CK occurrence (early CRRT), and 67 patients received CRRT beyond 4.8 h after peak CK occurrence (late CRRT). Multivariate logistic regression analysis showed that the time from CRRT initiation to the peak CK (per 1 h, OR 1.026, 95% CI 1.004–1.049, p = 0.023), late CRRT (OR 3.082, 95% CI 1.072–8.859, p = 0.037), elevated serum cardiac troponin I (cTnI) (per 1 ng/mL, OR 1.218, 95% CI 1.011–1.468, p = 0.038), older age (per 1 year, OR 1.042, 95% CI 1.003–1.081, p = 0.032), and need of mechanical ventilation support (OR 4.632, 95% CI 1.292–16.61, p = 0.019) were independent risk factors for 90-day mortality.Conclusions Earlier CRRT initiation before 4.8 h after peak CK occurrence was associated with lower 90-day patient mortality.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0886022X
1525-6049
0886-022X
Relation: https://doaj.org/toc/0886-022X; https://doaj.org/toc/1525-6049
DOI: 10.1080/0886022X.2022.2132170
URL الوصول: https://doaj.org/article/d055a64793d64a6b93818422bf6b9e9b
رقم الأكسشن: edsdoj.055a64793d64a6b93818422bf6b9e9b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:0886022X
15256049
DOI:10.1080/0886022X.2022.2132170