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An Overview of Multiple Sclerosis In Vitro Models

التفاصيل البيبلوغرافية
العنوان: An Overview of Multiple Sclerosis In Vitro Models
المؤلفون: Joanna Czpakowska, Mateusz Kałuża, Piotr Szpakowski, Andrzej Głąbiński
المصدر: International Journal of Molecular Sciences, Vol 25, Iss 14, p 7759 (2024)
بيانات النشر: MDPI AG, 2024.
سنة النشر: 2024
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: multiple sclerosis, in vitro, pluripotent stem cells, 3D culture, cell culture, cellular models, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Multiple sclerosis (MS) still poses a challenge in terms of complex etiology, not fully effective methods of treatment, and lack of healing agents. This neurodegenerative condition considerably affects the comfort of life by causing difficulties with movement and worsening cognition. Neuron, astrocyte, microglia, and oligodendrocyte activity is engaged in multiple pathogenic processes associated with MS. These cells are also utilized in creating in vitro cellular models for investigations focusing on MS. In this article, we present and discuss a summary of different in vitro models useful for MS research and describe their development. We discuss cellular models derived from animals or humans and present in the form of primary cell lines or immortalized cell lines. In addition, we characterize cell cultures developed from induced pluripotent stem cells (iPSCs). Culture conditions (2D and 3D cultures) are also discussed.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
1661-6596
Relation: https://www.mdpi.com/1422-0067/25/14/7759; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms25147759
URL الوصول: https://doaj.org/article/06d295fe68ce4bcda6eb168d2eb42cf2
رقم الأكسشن: edsdoj.06d295fe68ce4bcda6eb168d2eb42cf2
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
16616596
DOI:10.3390/ijms25147759