دورية أكاديمية
Effect of Statin Intensity on the Progression of Cardiac Allograft Vasculopathy
| العنوان: | Effect of Statin Intensity on the Progression of Cardiac Allograft Vasculopathy |
|---|---|
| المؤلفون: | Tracey M Ellimuttil, Kimberly Harrison, Allman T Rollins, Irene D Feurer, Scott A Rega, Jennifer Gray, Jonathan N Menachem |
| المصدر: | Cardiac Failure Review, Vol 7, Iss , Pp - (2021) |
| بيانات النشر: | Radcliffe Medical Media, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Background: In the non-transplant population, hyperlipidaemia has shifted from targeting LDL goals to statin intensity-based treatment. It is unknown whether this strategy is also beneficial in cardiac transplantation. Methods: This single-centre retrospective study evaluated the effect of statin use and intensity on time to cardiac allograft vasculopathy (CAV) after cardiac transplantation. Kaplan–Meier and Cox proportional hazards regression survival methods were used to assess the association of statin intensity and median post-transplant LDL on CAV-free survival. Results: The study involved 143 adults (71% men, average follow-up of 25 ± 14 months) who underwent transplant between 2013 and 2017. Mean CAV-free survival was 47.5 months (95% CI [43.1–51.8]), with 29 patients having CAV grade 1 or greater. Median LDL was not associated with time to CAV (p=0.790). CAV-free survival did not differ between intensity groups (p=0.435). Conclusion: Given the non-statistically significant difference in time to CAV with higher intensity statins, the data suggest that advancing moderate- or high-intensity statin after cardiac transplantation may not provide additional long-term clinical benefit. Trial registration: Not applicable. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2057-7559 2057-7540 |
| Relation: | https://www.cfrjournal.com/articleindex/cfr.2021.07; https://doaj.org/toc/2057-7540; https://doaj.org/toc/2057-7559 |
| DOI: | 10.15420/cfr.2021.07 |
| URL الوصول: | https://doaj.org/article/06f56a7e51da4736ba2419a7a39ea90c |
| رقم الأكسشن: | edsdoj.06f56a7e51da4736ba2419a7a39ea90c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20577559 20577540 |
|---|---|
| DOI: | 10.15420/cfr.2021.07 |