دورية أكاديمية
The chemokine Cxcl14 regulates interneuron differentiation in layer I of the somatosensory cortex
| العنوان: | The chemokine Cxcl14 regulates interneuron differentiation in layer I of the somatosensory cortex |
|---|---|
| المؤلفون: | Andrew F. Iannone, Gülcan Akgül, Robin Zhang, Sam Wacks, Nisma Hussein, Carmen Ginelly Macias, Alexander Donatelle, Julia M.J. Bauriedel, Cora Wright, Debra Abramov, Megan A. Johnson, Eve-Ellen Govek, Jacqueline Burré, Teresa A. Milner, Natalia V. De Marco García |
| المصدر: | Cell Reports, Vol 43, Iss 8, Pp 114531- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | CP: Neuroscience, Biology (General), QH301-705.5 |
| الوصف: | Summary: Spontaneous and sensory-evoked activity sculpts developing circuits. Yet, how these activity patterns intersect with cellular programs regulating the differentiation of neuronal subtypes is not well understood. Through electrophysiological and in vivo longitudinal analyses, we show that C-X-C motif chemokine ligand 14 (Cxcl14), a gene previously characterized for its association with tumor invasion, is expressed by single-bouquet cells (SBCs) in layer I (LI) of the somatosensory cortex during development. Sensory deprivation at neonatal stages markedly decreases Cxcl14 expression. Additionally, we report that loss of function of this gene leads to increased intrinsic excitability of SBCs—but not LI neurogliaform cells—and augments neuronal complexity. Furthermore, Cxcl14 loss impairs sensory map formation and compromises the in vivo recruitment of superficial interneurons by sensory inputs. These results indicate that Cxcl14 is required for LI differentiation and demonstrate the emergent role of chemokines as key players in cortical network development. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2211-1247 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S221112472400860X; https://doaj.org/toc/2211-1247 |
| DOI: | 10.1016/j.celrep.2024.114531 |
| URL الوصول: | https://doaj.org/article/e07561a1087342f3a075543052cb6cd3 |
| رقم الأكسشن: | edsdoj.07561a1087342f3a075543052cb6cd3 |
| قاعدة البيانات: | Directory of Open Access Journals |
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